PLEC anticorps

N° du produit ABIN7489970

Détail du produit anti-PLEC anticorps

Antigène: PLEC (Plectin (PLEC))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp PLEC est non-conjugé

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Affinity purification

Immunogène: Recombinant protein of human Plectin .

Clone: ARC53240

Isotype: IgG

Information d'application

Indications d'application: IHC-P 1:100 – 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze / thaw cycles.

Stock: -20 °C

Détails sur PLEC

Antigène: PLEC (Plectin (PLEC))

Autre désignation: Plectin (PLEC Produits)

Synonymes: anticorps EBS1, anticorps EBSO, anticorps HD1, anticorps LGMD2Q, anticorps PCN, anticorps PLEC1, anticorps PLEC1b, anticorps PLTN, anticorps AA591047, anticorps AU042537, anticorps Plec1, anticorps Pcn, anticorps Pltn, anticorps IFAP300, anticorps Plectin-1, anticorps plectin, anticorps plectin L homeolog, anticorps LOC100481602, anticorps plec.L, anticorps PLEC, anticorps Plec, anticorps LOC786966

Sujet: Synonyms: HD1; PCN; EBS1; EBSO; PLTN; EBS5A; EBS5B; EBS5C; EBS5D; EBSMD; EBSND; EBSOG; EBSPA; PLEC1; LGMD2Q; PLEC1b; LGMDR17; Plectin
Background: Plectin is a large, widely expressed protein that crosslinks the intermediate filament and actin cytoskeleton, mechanically stabilizing cells and tissues. Plectin also plays a role in the regulation of actin dynamics and acts as a scaffold for signaling molecules. Plectin is important in the stabilization of hemidesmosomes, crosslinking them to the intermediate filament network. Research studies have shown that mutations in plectin and other genes coding for hemidesmosomal proteins can cause epidermolysis bullosa, a condition manifested by fragile skin and frequent blistering . Plectin modulates signals to PKC through binding and sequestration of RACK1, the receptor for activated C kinase 1 . Plectin is also involved in the regulation of cytokeratin architecture and cell stress response , signaling through the chemokine receptor CXCR4 and regulation of AMP-activated protein kinase (AMPK) activity and signaling in mouse myotubes .

ID gène: 5339

UniProt: Q15149