beta-2 Microglobulin anticorps (AA 21-119)

N° du produit ABIN7538095

Cet anticorps anti-beta-2 Microglobulin Polyclonal Lapin (ABIN7538095) détecte spécifiquement beta-2 Microglobulin dans WB et ELISA. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour beta-2 Microglobulin anticorps (AA 21-119) (ABIN7538095)

Antigène: beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp beta-2 Microglobulin est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-beta-2 Microglobulin anticorps

Épitope: AA 21-119

Fonction: Rabbit polyclonal antibodies to Beta-2-Microglobulin

Specificité: Beta-2-microglobulin

Réactivité croisée (Details): May cross-react with other species

Purification: Immunogen affinity column

Immunogène: B2MG_Human 21-119 

Isotype: IgG, IgM

Information d'application

Indications d'application: Western blot: 0.1-1.0 μg/mL

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Glycine pH 7.2

Stock: 4 °C,-80 °C

Stockage commentaire: Short term up to 1 month at 2-8°C, long term can be held for up to five years at -70°C

Détails sur beta-2 Microglobulin

Antigène: beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

Autre désignation: Beta-2-Microglobulin

Sujet: Beta-2-microglobulin (B2M) is a 12-14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I. Human beta 2 Microglobulin associated with HLA Class I antigens are expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but is absent on erythrocytes. Beta-2 microglobulin is also found in free form in the plasma. The amino acid sequence of Beta-2-microglobulin is homologous to the constant regions of immunoglobulin heavy and light chains, with a predominantly beta pleated sheet structure. The protein is ubiquitously expressed in the cytoplasm, and is involved in antigen processing and presentation. Beta-2-microglobulin also plays a role in TCR signaling, and downstream signaling in naive CD8+ cells. Beta 2-microglobulin is encoded by the B2M gene located on chromosome 15. A mutation in the Beta-2-microglobulin gene has been shown to result in hypercatabolic hypoproteinemia. Levels of beta 2 microglobulin can be used to assess renal function in kidney transplant recipients. Beta-2-microglobulin that protein can be used as a prognostic marker for HIV infection.

Poids moléculaire: 11731 Da

ID gène: 567

NCBI Accession: NP_004039

UniProt: P61769

Pathways: TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process