Presenilin 1 anticorps (AA 299-350) (HRP)
Aperçu rapide pour Presenilin 1 anticorps (AA 299-350) (HRP) (ABIN723794)
Antigène
Voir toutes Presenilin 1 (PSEN1) AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
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Épitope
- AA 299-350
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Réactivité croisée
- Humain
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Homologie
- Mouse,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit
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Purification
- Purified by Protein A.
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Immunogène
- KLH conjugated synthetic peptide derived from human Presenilin-1 CTF subunit
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Isotype
- IgG
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anti-Presenilin 1 (PSEN1) (AA 1-160) antibody
PSEN1 Reactivité: Humain WB, IHC, IF Hôte: Lapin Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (AA 330-359), (C-Term) antibodyPSEN1 Reactivité: Humain, Souris WB, IHC (p), FACS, IF Hôte: Lapin Polyclonal RB2257 unconjugated
anti-Presenilin 1 (PSEN1) (pSer310) antibodyKD Validated PSEN1 Reactivité: Humain WB, FACS Hôte: Lapin Monoclonal 24GB4510 unconjugated Recombinant Antibody
anti-Presenilin 1 (PSEN1) (AA 4-218) antibodyPSEN1 Reactivité: Humain WB, ELISA, IHC Hôte: Lapin Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (Middle Region) antibodyPSEN1 Reactivité: Humain, Souris, Rat, Boeuf (Vache), Cobaye, Chien, Cheval, Lapin WB, IHC, IP Hôte: Lapin Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (AA 1-160) antibodyPSEN1 Reactivité: Humain WB, ELISA, IHC Hôte: Lapin Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (AA 300-349) antibodyPSEN1 Reactivité: Humain, Souris, Singe, Boeuf (Vache), Porc, Cobaye, Cheval WB, IHC, IHC (p) Hôte: Lapin Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (AA 107-156) antibodyPSEN1 Reactivité: Humain, Souris, Rat, Singe, Porc, Cobaye, Chien, Roussette (Chauve-souris), Hamster WB, IHC, IHC (p) Hôte: Lapin Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (N-Term) antibodyPSEN1 Reactivité: Humain, Souris, Rat, Boeuf (Vache), Cobaye, Chien, Cheval, Lapin, Poisson zèbre (Danio rerio) WB, IHC Hôte: Lapin Polyclonal unconjugated
anti-Presenilin 1 (PSEN1) (Ser45), (Thr41) antibodyPSEN1 Reactivité: Humain, Souris, Rat WB, ELISA, IHC Hôte: Lapin Polyclonal unconjugated
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Indications d'application
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WB 1:300-5000
IHC-F 1:100-500 -
Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 μg/μL
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Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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Agent conservateur
- ProClin
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Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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Conseil sur la manipulation
- Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
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Stock
- -20 °C
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Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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Date de péremption
- 12 months
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- Presenilin 1 (PSEN1)
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Autre désignation
- presenilin 1
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Sujet
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Synonyms: PS1, Ad3h, PS-1, S182, Presenilin-1, Protein S182, Psen1, Psnl1
Background: Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis (By similarity).
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ID gène
- 5663
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UniProt
- P49768
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Pathways
- Signalisation Notch, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
Antigène
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