Neuregulin 1 anticorps (Extracellular)

N° du produit ABIN7886663

Cet anticorps Lapin Polyclonal détecte spécifiquement Neuregulin 1 dans WB et IHC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Neuregulin 1 anticorps (Extracellular) (ABIN7886663)

Antigène: Neuregulin 1 (NRG1)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Neuregulin 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Neuregulin 1 anticorps

Épitope: AA 101-113, Extracellular

Fonction: A Rabbit Polyclonal Antibody to Neuregulin-1 Type III

Séquence: (C)DKIFEYDSPT HLD

Réactivité croisée (Details): This antibody will recognize Neuregulin-1 Type III. It will not recognize Neuregulin-1 Type I, Type II and Type IV.

Homologie: Rat,mouse - identical

Attributs du produit: Anti-NRG1 Type III (extracellular) Antibody (ABIN7581925) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize NRG1 Type III from rat, human and mouse samples. The antibody is specific for NRG1 Type III and does not recognize other Neuregulin-1 isoforms.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)DKIFEYDSPTHLD, corresponding to amino acid residues 101-113 of human Neuregulin-1 Type III

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Neuregulin 1

Antigène: Neuregulin 1 (NRG1)

Autre désignation: NRG1

Sujet:

Synonyms: Neuregulin-1 isoform 10, CRD-NRG, Sensory and motor neuron derived factor, SMDF

Description: Neuregulin-1 (NRG1) is a member of a subfamily of the epidermal growth factor family and plays an important role in the development of the peripheral nervous system. Through alternative RNA splicing and promoter usage, the NRG1 gene encodes an entire family of more than 15 transmembrane and secreted isoforms. Neuregulin-1 acts as an important regulator in the survival of Schwann cell precursors, Schwann cell proliferation, motility, axon ensheathment and myelination.Neuregulin-1 can be divided into different according to the N-terminal sequence. Neuregulin-1 Type III, a transmembrane protein, contains an epidermal growth factor-like domain, which alone is adequate to bind and activate ErbB receptor tyrosine kinases. Type III also contains a cysteine-rich domain called "cysteine-rich domain-neuregulins," that requires a proteolytic cleavage for full activity1,2.Knockout studies show that type III is the key isoform required for schwann cell generation. These studies also confirmed that type III isoform is necessary for promoting myelination and to regulate myelin thickness1,2. Several different studies also showed that NRG1 Type III isoform is also an important regulator of cholinergic signaling. Neuregulin-1 Type III regulates the expression of AChR genes and targeting of nAChRs to the neuronal cell surface. This isoform in particular is a critical regulator of presynaptic targeting of α7-containing nAChRs3.

ID gène: 3084

UniProt: Q02297

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation