TLR8 anticorps (N-Term)

N° du produit ABIN7603240

L’anticorps Lapin Polyclonal anti-TLR8 a été validé pour WB et IHC. Il convient pour détecter TLR8 dans des échantillons de Souris et Rat.

Aperçu rapide pour TLR8 anticorps (N-Term) (ABIN7603240)

Antigène: TLR8 (Toll-Like Receptor 8 (TLR8))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TLR8 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-TLR8 anticorps

Épitope: N-Term

Fonction: Anti-Tlr8 Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-Tlr8 Antibody Picoband® (ABIN7603240). Tested in IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of mouse Tlr8, which shares 76.5% amino acid (aa) sequence identity with human TLR8.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Mouse
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Mouse, Rat
1. Chuang, T.-H., Ulevitch, R. J.Cloning and characterization of a sub-family of human Toll-like receptors: hTLR7, hTLR8 and hTLR9.Europ. Cytokine Netw. 11: 372-378, 2000. 2. Kadowaki, N., Ho, S., Antonenko, S., de Waal Malefyt, R., Kastelein, R. A., Bazan, F., Liu, Y.-J.Subsets of human dendritic cell precursors express different Toll-like receptors and respond to different microbial antigens.J. Exp. Med. 194: 863-869, 2001. 3. Peng, G., Guo, Z., Kiniwa, Y., Voo, K., Peng, W., Fu, T., Wang, D. Y., Li, Y., Wang, H. Y., Wang, R.-F.Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function.Science 309: 1380-1384, 2005.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur TLR8

Antigène: TLR8 (Toll-Like Receptor 8 (TLR8))

Autre désignation: Tlr8

Sujet:

Synonyms: Nuclear factor 1 B-type, NF1-B, Nuclear factor 1/B, CCAAT-box-binding transcription factor, CTF, Nuclear factor I/B, NF-I/B, NFI-B, TGGCA-binding protein, NFIB

Background: TLR8 (Toll-like receptor 8) is a protein that in humans is encoded by the TLR8 gene. TLR8 has also been designated as CD288 (cluster of differentiation 288).The TLR8 gene is mapped to Xp22.3-p22.2 by Chuang and Ulevitch (2000) and Du et al. (2000). The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. TLR8 recognises G-rich oligonucleotides.

Poids moléculaire: 119 kDa

ID gène: 170744

UniProt: P58682

Pathways: Signalisation TLR, Activation of Innate immune Response, Toll-Like Receptors Cascades