MHC Class II HLA-DP/DQ/DR anticorps (CF®568)

N° du produit ABIN7657067

L’anticorps anti-MHC Class II HLA-DP/DQ/DR Monoclonal Souris est utilisé pour la détection de MHC Class II HLA-DP/DQ/DR dans des échantillons de Humain. Il a été validé pour FACS, IF, WB, IHC et IHC (fp).

Aperçu rapide pour MHC Class II HLA-DP/DQ/DR anticorps (CF®568) (ABIN7657067)

Antigène: MHC Class II HLA-DP/DQ/DR (HLA-DP/DQ/DR)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MHC Class II HLA-DP/DQ/DR est conjugé à/à la CF®568

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: CR3-43

Détail du produit anti-MHC Class II HLA-DP/DQ/DR anticorps (CF®568)

Fonction: HLA-DP/-DQ/-DR (MHC II)(CR3/43), CF568 conjugate

Attributs du produit: Reacts with a common epitope of human major histocompatibility (MHC) class II antigens, HLA-DP, -DQ and -DR. Human MHC class II antigens are transmembrane glycoproteins composed of an chain (36 kDa) and a chain (27 kDa). They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, and thymic epithelial cells and are also present on activated T lymphocytes. Human MHC class II genes are located in the HLA-D region that encodes at least six and ten chain genes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They, therefore, have a critical role in the initiation of the immune response. It has been shown that some autoimmune diseases are associated with certain class II alleles. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogène: Cells from human tonsil

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Positive Control: Ramos, Raji cells. Tonsil, Spleen or lymph node.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from light

Stock: 4 °C

Stockage commentaire:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Date de péremption: 24 months

Détails sur MHC Class II HLA-DP/DQ/DR

Antigène: MHC Class II HLA-DP/DQ/DR (HLA-DP/DQ/DR)

Autre désignation: HLA-DP/-DQ/-DR

Sujet:

Synonyms: HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5,

Gene Symbol: HLA-DP, HLA-DQ, HLA-DR

Poids moléculaire: 36 kDa (? chain) and 27 kDa (? chain)

ID gène: 3115, 3117, 3122

UniProt: P04440, P01908, P01909, P01920, P01903

Pathways: Human Leukocyte Antigen (HLA) in Adaptive Immune Response