NADPH Oxidase 4 anticorps (CF®740)

N° du produit ABIN7657692

Cet anticorps anti-NADPH Oxidase 4 est un anticorps Souris Monoclonal détectant NADPH Oxidase 4 dans . Adapté pour Humain.

Aperçu rapide pour NADPH Oxidase 4 anticorps (CF®740) (ABIN7657692)

Antigène: NADPH Oxidase 4 (NOX4)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NADPH Oxidase 4 est conjugé à/à la CF®740

Application: Veuillez nous consulter SVP

Clone: NOX4-1245

Détail du produit anti-NADPH Oxidase 4 anticorps (CF®740)

Fonction: NOX4 / NADPH Oxidase 4 (NOX4/1245), CF740 conjugate

Attributs du produit: The superoxide-generating NADPH oxidase includes a membrane-bound flavocytochrome containing two subunits, gp91-phox and p22-phox, and the cytosolic proteins p47-phox and p67-phox. During activation of the NADPH oxidase, p47-phox and p67-phox migrate to the plasma membrane where they associate with the flavocytochrome, cytochrome b558, to form the active enzyme complex. The p22 and gp91-phox subunits also function as surface O2 sensors that initiate cellular signaling in response to hypoxic conditions. NOX4 is a renal gp91-phox homolog highly expressed at the site of erythropoietin production in the proximal convoluted tubule epithelial cells of the renal cortex. It is also expressed in fetal tissues, placenta, glioblastoma and vascular cells.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogène: Recombinant human NOX4 protein

Isotype: IgG2b, kappa

Information d'application

Indications d'application: For coating for ELISA, order Ab without BSA. Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody. Optimal dilution and staining procedure for a specific application should be determined by user. Recommended starting concentrations for titration are 1-2 μg/mL for most applications, or 1 μg/million cells/100 μLfor flow cytometry

Commentaires:

Positive Control: PC-12, JAR cells. Kidney

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % rBSA, 0.05 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from light

Stock: 4 °C

Stockage commentaire:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Date de péremption: 24 months

Détails sur NADPH Oxidase 4

Antigène: NADPH Oxidase 4 (NOX4)

Autre désignation: NADPH-Oxidase-4

Sujet:

Synonyms: Kidney oxidase-1, Kidney superoxide-producing NADPH oxidase, KOX-1, NADPH oxidase 4, Nox4, Renal NAD(P)H-oxidase, RENOX

Gene Symbol: NOX4

Tissue Expression: Endothelial cells|Kidney

Poids moléculaire: 70 kDa

ID gène: 50507

UniProt: Q9NPH5

Pathways: Carbohydrate Homeostasis, Smooth Muscle Cell Migration