ErbB2/Her2 anticorps

N° du produit ABIN8062515

Cet anticorps anti-ErbB2/Her2 Monoclonal Souris (Clone SER4) (ABIN8062515) détecte spécifiquement ErbB2/Her2 dans FACS. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour ErbB2/Her2 anticorps (ABIN8062515)

Antigène: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ErbB2/Her2 est non-conjugé

Application: Flow Cytometry (FACS)

Clone: SER4

Détail du produit anti-ErbB2/Her2 anticorps

Fonction: Purified Anti-Human CD340 Antibody[SER4]

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: ≥ 1 mg/mL

Buffer: Phosphate buffered solution, pH 7.2, containing 0.05 % proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: avoid freeze / thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Date de péremption: 12 months

Détails sur ErbB2/Her2

Antigène: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Autre désignation: CD340

Sujet: TKR,ERBB,erb-b2 receptor tyrosine kinase,Receptor tyrosine-protein kinase erbB,Tyrosine kinase-type cell surface receptor HER,HER2/ErbB,HER,MLN,ERBB2,CD340,HER-2,HER-2/neu,HER2,MLN 19,NEU,NGL,TKR1,erb-b2 receptor tyrosine kinase 2,HER2/ErbB2,MLN19,Metastatic lymph node gene 19 protein,p185,Proto-oncogene Neu,Receptor tyrosine-protein kinase erbB-2,Tyrosine kinase-type cell surface receptor HER2, Neu, erb-B2,CD340,erb-b2 receptor tyrosine kinase 2,HER2,HER-2,HER-2/neu,MLN 19,MLN19,NGL,TKR1,C erb B2/neu protein,CD340 antigen,Cerb B2/neu protein,CerbB2,ENV,ENVW,Erb b2 receptor tyrosine kinase 2,ERVWE1,HER 2,HER 2/NEU,Herstatin,HERV7Q,HERV-7q,HERVW,HERVWENV,HERV-W-ENV,Human epidermal growth factor receptor 2,NEU proto oncogene,neuro/glioblastoma derived oncogene homolog,neuro/glioblastoma derived oncogene homolog (avian),Neuroblastoma/glioblastoma derived oncogene homolog,p185erbB2,Proto-oncogene c-ErbB-2,Tyrosine kinase type cell surface receptor HER2,V erb b2 avian erythroblastic leukemia viral oncogene homolog 2,V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog),V erb b2 avian erythroblastic leukemia viral oncoprotein 2,V erb b2 erythroblastic leukemia viral oncogene homolog 2,Verb b2 erythroblastic leukemia viral oncogene homolog 2,ErbB2, also called Neu and Her2, is a transmembrane glycoprotein in the ErbB family of tyrosine kinase receptors for EGF superfamily growth factors. ErbB2 is widely expressed in epithelial cells and over-expressed in a large number of breast carcinomas. ErbB2 has no identified ligands but heterodimerizes with ErbB1/EGF R, ErbB3, or ErbB4 to form higher affinity signaling complexes. The protease ADAM10 releases a 110 kDa soluble fragment of ErbB2 from the cell surface. ErbB2 plays roles in development, cancer, communication at the neuromuscular junction, and regulation of cell growth and differentiation. The ErbB2/ErbB3 heterodimer is expressed in the majority of breast, skin, ovary and gastrointestinal tumors and transduces a highly mitogenic signal in response to neuregulin 1 (NRG1, heuregulin 1) or NRG2. ErbB3, ErbB2 and neuregulin are all required for formation of the sympathetic nervous system.

UniProt: P04626

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development