IGFBP5 anticorps

N° du produit ABIN7670642

Cet anticorps Souris Monoclonal détecte spécifiquement IGFBP5 dans ELISA (Capture). Il présente une réactivité envers Humain.

Aperçu rapide pour IGFBP5 anticorps (ABIN7670642)

Antigène: IGFBP5 (Insulin-Like Growth Factor Binding Protein 5 (IGFBP5))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IGFBP5 est non-conjugé

Application: ELISA (Capture)

Clone: 8F12

Détail du produit anti-IGFBP5 anticorps

Fonction: IGFBP-5 Monoclonal Antibody(Capture)

Purification: Protein A/G Purification

Immunogène: Recombinant Human IGFBP-5 protein expressed by E.coli

Isotype: IgG2b

Information d'application

Indications d'application: ELISA Capture 2-8 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Sterile PBS , pH 7.4

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C Valid for 1 month or -20°C Valid for 12 months

Date de péremption: 12 months

Détails sur IGFBP5

Antigène: IGFBP5 (Insulin-Like Growth Factor Binding Protein 5 (IGFBP5))

Autre désignation: IGFBP-5

Sujet: IBP5,IGFBP5,IBP-5,IGF-binding protein 5,IGFBP-5,InsuLin-Like growth factor-binding protein 5,The superfamily of insulin-like growth factor (IGF) binding proteins include the six high-affinity IGF binding proteins (IGFBP) and at least four additional low-affinity binding proteins referred to as IGFBP related proteins (IGFBP-rP). All IGFBP superfamily members are cysteine-rich proteins with conserved cysteine residues,which are clustered in the amino- and carboxy-terminal thirds of the molecule. IGFBPs modulate the biological activities of IGF proteins. Some IGFBPs may also have intrinsic bioactivity that is independent of their ability to bind IGF proteins. Post-translational modifications of IGFBPs,including glycosylation,phosphorylation and proteolysis,have been shown to modify the affinities of the binding proteins to IGF. Mouse IGFBP-5 cDNA encodes a 271 amino acid (aa) residue precursor protein with a putative 19 aa residue signal peptide that is processed to generate the 252 aa residue mature protein. Mouse,human and rat IGFBP-5 share 97 % identity. IGFBP-5 is expressed by fibroblasts,myoblasts and osteoblasts,making it the predominant IGFBP found in bone extracts. IGFBP-5 has a strong affinity for hydroxyapatite,allowing it to bind to bone cells. When bound to extracelluar matrix,IGFBP-5 is protected from proteolysis and potentiates IGF activity,but when it is soluble,IGFBP-5 is cleaved to a biologically inactive 21 kDa fragment.

UniProt: P24593

Pathways: Signalisation WNT, Carbohydrate Homeostasis, Myometrial Relaxation and Contraction, Regulation of Carbohydrate Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Growth Factor Binding