RANKL anticorps

N° du produit ABIN7670758

Cet anticorps anti-RANKL Monoclonal Souris (Clone 4D4) (ABIN7670758) détecte spécifiquement RANKL dans ELISA. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour RANKL anticorps (ABIN7670758)

Antigène: RANKL (TNFSF11) (Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp RANKL est non-conjugé

Application: ELISA

Clone: 4D4

Détail du produit anti-RANKL anticorps

Fonction: TRANCE/RANKL/TNFSF11 Monoclonal Antibody(Capture/Detector)

Purification: Protein A/G Purification

Immunogène: Recombinant Human TRANCE/RANKL/TNFSF11 protein expressed by E.coli

Isotype: IgG1

Information d'application

Indications d'application: ELISA Capture 2-8 μg/mL,ELISA Detector 0.1-0.4 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Sterile PBS , pH 7.4

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C Valid for 1 month or -20°C Valid for 12 months

Date de péremption: 12 months

Détails sur RANKL

Antigène: RANKL (TNFSF11) (Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))

Autre désignation: TRANCE/RANKL/TNFSF11

Sujet: CD254,TNFSF11,OPGL,RANKL,TRANCE,Tumor necrosis factor Ligand superfamiLy member 11,OsteocLast differentiation factor (ODF),Osteoprotegerin Ligand (OPGL),Receptor activator of nucLear factor kappa-B Ligand (RANKL),TNF-reLated activation-induced cytokine (TRANCE),Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells,chief among which is induction of long lasting oscillations in the intracellular concentration of Ca 2+ resulting in the activation of NFATC1,which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation,in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation.

UniProt: O14788

Pathways: Signalisation NF-kappaB