RANKL anticorps (AA 221-300)

N° du produit ABIN668556

Détail du produit anti-RANKL anticorps

Antigène: RANKL (TNFSF11) (Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))

Épitope: AA 221-300

Reactivité: Humain, Souris, Rat, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RANKL est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Souris, Lapin, Rat

Homologie: Dog,Cow

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from mouse OPG

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-RANKL (ABIN668556)

Kerschan-Schindl, Schramek, Butylina, Föger-Samwald, Pietschmann: "Differential Expression of Dickkopf 1 and Periostin in Mouse Strains with High and Low Bone Mass." dans: Biology, Vol. 11, Issue 12, (2022) (PubMed).

Zhan, Liu, Wang: "The Role of MicroRNA-143-5p in the Differentiation of Dental Pulp Stem Cells into Odontoblasts by Targeting Runx2 via the OPG/RANKL Signaling Pathway." dans: Journal of cellular biochemistry, Vol. 119, Issue 1, pp. 536-546, (2018) (PubMed).

Yu, Gong, Lin, Wang, Liu, Li: "Denervation effectively aggravates rat experimental periodontitis." dans: Journal of periodontal research, Vol. 52, Issue 6, pp. 1011-1020, (2017) (PubMed).

Zhang, Chen, Wei, Liu, Lei, Bai: "Ginsenosides Rg3 attenuates glucocorticoid-induced osteoporosis through regulating BMP-2/BMPR1A/Runx2 signaling pathway." dans: Chemico-biological interactions, Vol. 256, pp. 188-97, (2016) (PubMed).

Chen, Xue, Shen, Mu, Fu: "Curcumin alleviates glucocorticoid-induced osteoporosis through the regulation of the Wnt signaling pathway." dans: International journal of molecular medicine, Vol. 37, Issue 2, pp. 329-38, (2016) (PubMed).

He, Wang, Wang, Tian, Jiang, Ren, Qiu, Fu: "Effect of glucocorticoids on osteoclast function in a mouse model of bone necrosis." dans: Molecular medicine reports, Vol. 14, Issue 2, pp. 1054-60, (2016) (PubMed).

Xiao, Hu, Li, Li: "Bone fracture healing is delayed in splenectomic rats." dans: Life sciences, Vol. 173, pp. 55-61, (2016) (PubMed).

Zhang, Liu, Li, Bai: "Mycobacterium tuberculosis 10-kDa co-chaperonin regulates the expression levels of receptor activator of nuclear factor-?B ligand and osteoprotegerin in human osteoblasts." dans: Experimental and therapeutic medicine, Vol. 9, Issue 3, pp. 919-924, (2015) (PubMed).

Yu, Lv, Zhang, Zhang, Xiao, Li: "Expression of neuropeptides and bone remodeling-related factors during periodontal tissue regeneration in denervated rats." dans: Journal of molecular histology, Vol. 46, Issue 2, pp. 195-203, (2015) (PubMed).

Herath, Lion, Klein, Stenger, Scheuer, Holstein, Mörsdorf, Rollmann, Pohlemann, Menger, Histing: "Stimulation of angiogenesis by cilostazol accelerates fracture healing in mice." dans: Journal of orthopaedic research : official publication of the Orthopaedic Research Society, (2015) (PubMed).

Li, Wu, Ma, Hao, Chen, Fu, Chen, Wang: "Oral administration of 5-hydroxytryptophan aggravated periodontitis-induced alveolar bone loss in rats." dans: Archives of oral biology, Vol. 60, Issue 5, pp. 789-98, (2015) (PubMed).

Yang, Li, Yang, Shen, Zou, Zhu, Zhang, Yang, Li: "Efficacy and safety of echinacoside in a rat osteopenia model." dans: Evidence-based complementary and alternative medicine : eCAM, Vol. 2013, pp. 926928, (2013) (PubMed).

Détails sur RANKL

Antigène: RANKL (TNFSF11) (Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))

Autre désignation: OPG (TNFSF11 Produits)

Synonymes: anticorps CD254, anticorps ODF, anticorps OPGL, anticorps OPTB2, anticorps RANKL, anticorps TRANCE, anticorps hRANKL2, anticorps sOdf, anticorps TNFSF11, anticorps Ly109l, anticorps OPG, anticorps Trance, anticorps cd254, anticorps odf, anticorps opgl, anticorps optb2, anticorps rankl, anticorps sodf, anticorps tnfsf11, anticorps trance, anticorps TNF superfamily member 11, anticorps tumor necrosis factor (ligand) superfamily, member 11, anticorps TNF receptor superfamily member 11b, anticorps TNF superfamily member 11 L homeolog, anticorps TNFSF11, anticorps Tnfsf11, anticorps TNFRSF11B, anticorps tnfsf11.L

Sujet:

Synonyms: Opg, TR1, OCIF, Tumor necrosis factor receptor superfamily member 11B, Osteoclastogenesis inhibitory factor, Osteoprotegerin, Tnfrsf11b

Background: Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF1/TRAIL and protect against apoptosis. TNFSF1/TRAIL binding blocks the inhibition of osteoclastogenesis.

ID gène: 18383

UniProt: O08712

Pathways: Signalisation NF-kappaB