Recombinant beta-2 Microglobulin anticorps

N° du produit ABIN7857967

Cet anticorps anti-beta-2 Microglobulin Monoclonal Souris (Clone rB2M-7279) (ABIN7857967) détecte spécifiquement beta-2 Microglobulin dans IHC. L’anticorps est réactif avec des échantillons de Humain et Non-Human Primate.

Aperçu rapide pour Recombinant beta-2 Microglobulin anticorps (ABIN7857967)

Antigène: beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Non-Human Primate

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp beta-2 Microglobulin est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: RB2M-7279

Détail du produit anti-beta-2 Microglobulin anticorps

Fonction: Recombinant Beta-2 Microglobulin (Renal Failure & Tumor Marker) Antibody

Specificité: Recognizes a protein of 12 kDa, identified as beta-2 microglobulin. Major histocompatibility complex (MHC) class 1 Molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 Molecules consist of an alpha heavy chain that contains three subdomains (alpha1, alpha2, alpha3) and a non-covalent associating light chain, known as beta-2-Microglobulin. Beta-2-Microglobulin associates with the alpha3 subdomain of the alpha heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 Molecules. The alpha1 and alpha2 domains of the alpha heavy chain form the peptide antigen-binding cleft. Mutations in the beta-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.

Purification: 200ug/ml of Ab purified by Protein A Column.

Immunogène: Recombinant full-length human B2M protein

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur beta-2 Microglobulin

Antigène: beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

Autre désignation: Beta-2 Microglobulin

Sujet:

B2M, Beta 2 microglobin, Beta 2 microglobulin, Beta chain of MHC class I molecules, Beta-2-microglobulin form pI 5.3, Hdcma22p

Cervix, Endometrial, HL-60 or HeLa cells. Human carcinomas of stomach, Kidney or Colon., Raji

Poids moléculaire: 12kDa

ID gène: 567, 534255

UniProt: P61769

Pathways: TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process