Bcl-2 anticorps (AA 1-200)

N° du produit ABIN7858364

Cet anticorps Souris Monoclonal détecte spécifiquement Bcl-2 dans IHC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Bcl-2 anticorps (AA 1-200) (ABIN7858364)

Antigène: Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Bcl-2 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: BCL2-6915

Détail du produit anti-Bcl-2 anticorps

Épitope: AA 1-200

Fonction: Bcl-2 (Apoptosis & Follicular Lymphoma Marker) Antibody

Specificité: This antibody recognizes a protein of 25-26 kDa, identified as the bcl-279 79oΩ 79oΩlpha oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of bcl-279 79oΩ 79oΩlpha oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-279 79oΩ 79oΩlpha protein, whereas the normal or hyperplastic germinal centers are negative.Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (around aa1-200) of human BCL2 protein (exact sequence is proprietary)

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur Bcl-2

Antigène: Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))

Autre désignation: Bcl-2

Sujet:

Apoptosis regulator Bcl-2, B-cell CLL/lymphoma-2

HL-60|Jurkat|K562|or HeLa cells. Tonsil or follicular lymphomas.

Poids moléculaire: 25-26kDa

ID gène: 596, 150749

Pathways: Signalisation MAPK, Signalisation PI3K-Akt, Apoptose, Caspase Cascade in Apoptosis, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagy, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling