FASL anticorps (AA 107-222)

N° du produit ABIN7863005

L’anticorps anti-FASL Monoclonal Souris est utilisé pour la détection de FASL dans des échantillons de Humain. Il a été validé pour IHC.

Aperçu rapide pour FASL anticorps (AA 107-222) (ABIN7863005)

Antigène: FASL (Fas Ligand (TNF Superfamily, Member 6) (FASL))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FASL est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: FASLG-4456

Détail du produit anti-FASL anticorps

Épitope: AA 107-222

Fonction: Fas Ligand (FASLG) Antibody

Specificité: Cytotoxic T lymphocyte (CTL)-mediated cytotoxicity constitutes an importantcomponent of specific effector mechanisms in immuno-surveillance againstvirus-infected or transformed cells. Two mechanisms appear to account forthis activity, one of which is the perforin-based process. Independently, aFAS-based mechanism involves the transducing molecule FAS (also designated Apo-1) and its ligand (FAS-L). The human FAS protein is a cell surfaceglycoprotein that belongs to a family of receptors that includes CD40, nervegrowth factor receptors and tumor necrosis factor receptors. The FAS antigen is expressed on a broad range of lymphoid cell lines, certain of whichundergo apoptosis in response to treatment with antibody to FAS. Thesefindings strongly imply that targeted cell death is potentially mediated by the intercellular interactions of FAS with its ligand or effectors, and that FASmay be critically involved in CTL-mediated cytotoxicity.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Human recombinant FASLG protein fragment (around aa107-222) (exact sequence is proprietary)

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur FASL

Antigène: FASL (Fas Ligand (TNF Superfamily, Member 6) (FASL))

Autre désignation: Fas Ligand

Sujet:

ALPS1B, Apoptosis (APO 1) antigen ligand 1, APT1LG1, APTL, CD178 antigen, CD95 ligand, Generalized lymphoproliferative disease, Gld, soluble form, TNFSF6, Tumor necrosis factor (ligand) superfamily member 6

Human tonsil or prostate.

Poids moléculaire: 26kDa (soluble FAS-L) / 40kDa (FAS-L membrane)

ID gène: 356, 2007

UniProt: P48023

Pathways: Apoptose, EGFR Signaling Pathway, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity