IGF1R anticorps (AA 550-750)

N° du produit ABIN7862981

Cet anticorps Souris Monoclonal détecte spécifiquement IGF1R dans FACS et IF. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour IGF1R anticorps (AA 550-750) (ABIN7862981)

Antigène: IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IGF1R est non-conjugé

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: IGF1R-4667

Détail du produit anti-IGF1R anticorps

Épitope: AA 550-750

Fonction: IGF1R / CD221 Antibody

Specificité: Receptor tyrosine kinases (RTKs) are transmembrane molecular scaffolds that influence cellular processes including the cell cycle, cell migration, cell metabolism, cell survival, proliferation and differentiation. Insulin-like growth factor-I receptor (IGF-IR) is an RTK that stimulates growth in many different cell types, blocks apoptosis, acts as an intermediate of many growth hormone responses and may stimulate the growth of some types of cancer. The IGF-IR cognate ligand Insulin-like growth factor-I (IGF-I) promotes association of IGF-IR with Shc, GRB2 and Sos 1, which initiates Ras and ERK kinase cascades, thereby modifying transcription factor activity, such as activation of the Elk transcription factors. The modular phosphotyrosine binding (PTB) domains of Insulin receptor substrate (IRS)-1 and -2 can associate with active IGF-IR and initiate phosphatidylinositol 3-kinase-dependent downstream signals. The human IGF-IR gene maps to chromosome 15q26.3 and encodes a 1,376 amino acid precursor protein that cleaves into °™ and æ subunits. The human IGF-IIR gene maps to chromosome 6q26 and encodes a 2,491 amino acid transmembrane protein.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (around aa550-750) of human IGF1R protein (exact sequence is proprietary)

Isotype: IgG2c, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur IGF1R

Antigène: IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

Autre désignation: IGF1R

Sujet:

CD221 antigen, IGF 1 receptor, IGF 1R, IGFIR, IGFIRC, IGFR, Insulin like growth factor 1 receptor precursor, Insulin-like growth factor 1 receptor beta chain, JTK13, Soluble IGF1R variant 1, Soluble IGF1R variant 2

Human breast carcinoma or colon carcinoma.

Poids moléculaire: 130kDa (IGF-1R), 97kDa (IGF-1R), 200kDa (pro-IGF-1R)

ID gène: 3480, 643120, 714012

UniProt: P08069

Pathways: Signalisation RTK, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagy