JAK3 anticorps (pTyr980, pTyr981)

N° du produit ABIN742883

L’anticorps Lapin Polyclonal anti-JAK3 a été validé pour ELISA. Il convient pour détecter JAK3 dans des échantillons de Humain.

Aperçu rapide pour JAK3 anticorps (pTyr980, pTyr981) (ABIN742883)

Antigène: JAK3 (Janus Kinase 3 (JAK3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp JAK3 est non-conjugé

Application: ELISA

Détail du produit anti-JAK3 anticorps

Épitope: pTyr980, pTyr981

Specificité: These phosphorylation sites are homologous to Tyr976 + Tyr977 in Mouse and Rat.

Homologie: Human,Mouse,Rat,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human Jak3 around the phosphorylation site of Tyr980/981

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur JAK3

Antigène: JAK3 (Janus Kinase 3 (JAK3))

Autre désignation: Jak3 +

Sujet:

Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 Molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.

Subcellular location: Cytoplasm

Synonyms: JAKL, LJAK, JAK-3, L-JAK, JAK3_HUMAN, Tyrosine-protein kinase JAK3, Janus kinase 3, Leukocyte janus kinase, JAK3

ID gène: 3718

UniProt: P52333

Pathways: Signalistation JAK/STAT, Signalisation RTK, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus, Activated T Cell Proliferation, Unfolded Protein Response