POU1F1 anticorps

N° du produit ABIN7861946

Cet anticorps Souris Monoclonal détecte spécifiquement POU1F1 dans IHC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour POU1F1 anticorps (ABIN7861946)

Antigène: POU1F1 (POU Class 1 Homeobox 1 (POU1F1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp POU1F1 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: PIT1-7262

Détail du produit anti-POU1F1 anticorps

Fonction: POU1F1 / PIT-1 Antibody

Specificité: Transcriptional regulators play a critical role in development by mediating tissue- and cell-specific transcription. POU domain factors are transcriptional regulators characterized by a bipartite DNA binding domain, which consists of two highly conserved regions, tethered by a variable linker of 14-26 amino acids. Pit-1, also known as growth hormone factor-1 (GHF-1), a member of the POU homeodomain family, is essential for the normal development of the anterior pituitary gland, where it is required for the formation of somatotropes, lactotropes and thyrotropes. In somatotropes and lactotropes, Pit-1 activates the production of growth hormone and Prolactin, respectively. In addition, Pit-1 acts as a repressor of gene expression, which allows for the differentiation of specific cell types. Pit-1 is expressed as two alternatively spliced products, designated Pit-1a and Pit-1b, which differ in their trans-activation ability. Mutations in the Pit-1 gene are believed to result in combined pituitary hormone deficiency (CPHD) for growth hormone, Prolactin and thyroid stimulating hormone. The gene which encodes Pit-1 maps to human chromosome 3p11.2.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant human full-length POU1F1 protein

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur POU1F1

Antigène: POU1F1 (POU Class 1 Homeobox 1 (POU1F1))

Autre désignation: POU1F1

Sujet:

Dwarf, GHF1A, Growth hormone factor 1, Hmp1, PiT-1, Pit1 beta, PIT1Z, Pituitary growth hormone, Pituitary specific positive transcription factor 1, POU domain class 1 transcription factor 1, POU domain transcriptional regulator, POU1F1

Human pituitary or tonsil.

Poids moléculaire: 31-35kDa

ID gène: 5449, 591654

UniProt: P28069

Pathways: Regulation of Carbohydrate Metabolic Process