POU1F1 anticorps (full length)

N° du produit ABIN7878832

Cet anticorps anti-POU1F1 Monoclonal Souris (Clone PIT1-7262) (ABIN7878832) détecte spécifiquement POU1F1 dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour POU1F1 anticorps (full length) (ABIN7878832)

Antigène: POU1F1 (POU Class 1 Homeobox 1 (POU1F1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp POU1F1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: PIT1-7262

Détail du produit anti-POU1F1 anticorps

Épitope: full length

Fonction: POU1F1 Antibody / PIT-1 / GHF-1

Purification: Protein A/G affinity

Immunogène: Recombinant human full-length protein was used as the immunogen for the POU1F1 antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the POU1F1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the POU1F1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur POU1F1

Antigène: POU1F1 (POU Class 1 Homeobox 1 (POU1F1))

Autre désignation: POU1F1

Sujet: Transcriptional regulators play a critical role in development by mediating tissue- and cell-specific transcription. POU domain factors are transcriptional regulators characterized by a bipartite DNA binding domain, which consists of two highly conserved regions, tethered by a variable linker of 14-26 amino acids. Pit-1, also known as growth hormone factor-1 (GHF-1), a member of the POU homeodomain family, is essential for the normal development of the anterior pituitary gland, where it is required for the formation of somatotropes, lactotropes and thyrotropes. In somatotropes and lactotropes, Pit-1 activates the production of growth hormone and Prolactin, respectively. In addition, Pit-1 acts as a repressor of gene expression, which allows for the differentiation of specific cell types. Pit-1 is expressed as two alternatively spliced products, designated Pit-1a and Pit-1b, which differ in their trans-activation ability. Mutations in the Pit-1 gene are believed to result in combined pituitary hormone deficiency (CPHD) for growth hormone, Prolactin and thyroid stimulating hormone. The gene which encodes Pit-1 maps to human chromosome 3p11.2.

UniProt: P28069

Pathways: Regulation of Carbohydrate Metabolic Process