FASL anticorps (AA 107-222)

N° du produit ABIN7870006

Cet anticorps anti-FASL Monoclonal Souris (Clone FASLG-4455) (ABIN7870006) détecte spécifiquement FASL dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour FASL anticorps (AA 107-222) (ABIN7870006)

Antigène: FASL (Fas Ligand (TNF Superfamily, Member 6) (FASL))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FASL est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: FASLG-4455

Détail du produit anti-FASL anticorps

Épitope: AA 107-222

Fonction: Fas Ligand Antibody

Purification: Protein G affinity chromatography

Immunogène: A portion of amino acids 107-222 from the human protein was used as the immunogen for the Fas Ligand antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the Fas Ligand antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Fas Ligand antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur FASL

Antigène: FASL (Fas Ligand (TNF Superfamily, Member 6) (FASL))

Autre désignation: Fas Ligand

Sujet: Cytotoxic T lymphocyte (CTL)-mediated cytotoxicity constitutes an importantcomponent of specific effector mechanisms in immuno-surveillance againstvirus-infected or transformed cells. Two mechanisms appear to account forthis activity, one of which is the perforin-based process. Independently, aFAS-based mechanism involves the transducing molecule FAS (also designated Apo-1) and its ligand (FAS-L). The human FAS protein is a cell surfaceglycoprotein that belongs to a family of receptors that includes CD40, nervegrowth factor receptors and tumor necrosis factor receptors. The FAS antigen is expressed on a broad range of lymphoid cell lines, certain of whichundergo apoptosis in response to treatment with antibody to FAS. Thesefindings strongly imply that targeted cell death is potentially mediated by the intercellular interactions of FAS with its ligand or effectors, and that FASmay be critically involved in CTL-mediated cytotoxicity.

UniProt: P48023

Pathways: Apoptose, EGFR Signaling Pathway, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity