MUS81 anticorps (AA 283-483)

N° du produit ABIN7873310

Cet anticorps Lapin Polyclonal détecte spécifiquement MUS81 dans ELISA et WB. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour MUS81 anticorps (AA 283-483) (ABIN7873310)

Antigène: MUS81 (MUS81 Endonuclease Homolog (MUS81))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MUS81 est non-conjugé

Application: ELISA, Western Blotting (WB)

Détail du produit anti-MUS81 anticorps

Épitope: AA 283-483

Fonction: MUS81 Antibody

Purification: Antigen affinity purified

Immunogène: Recombinant human protein (amino acids H283-R483) was used as the immunogen for the MUS81 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the MUS81 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the MUS81 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur MUS81

Antigène: MUS81 (MUS81 Endonuclease Homolog (MUS81))

Autre désignation: MUS81

Sujet: Crossover junction endonuclease MUS81 is an enzyme that in humans is encoded by the MUS81 gene. This gene encodes a structure-specific endonuclease which belongs to the XPF/MUS81 endonuclease family and plays a critical role in the resolution of recombination intermediates during DNA repair after inter-strand cross-links, replication fork collapse, and DNA double-strand breaks. The encoded protein associates with one of two closely related essential meiotic endonuclease proteins (EME1 or EME2) to form a complex that processes DNA secondary structures. It contains an N-terminal DEAH helicase domain, an excision repair cross complementation group 4 (ERCC4) endonuclease domain, and two tandem C-terminal helix-hairpin-helix domains. Mice with a homozygous knockout of the orthologous gene have significant meiotic defects including the failure to repair a subset of DNA double strand breaks.

UniProt: Q96NY9

Pathways: Réparation de l'ADN