Kallikrein 5 anticorps (AA 36-177)

N° du produit ABIN7874302

Cet anticorps anti-Kallikrein 5 Monoclonal Souris (Clone KLK5-3844) (ABIN7874302) détecte spécifiquement Kallikrein 5 dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Kallikrein 5 anticorps (AA 36-177) (ABIN7874302)

Antigène: Kallikrein 5 (KLK5)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Kallikrein 5 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: KLK5-3844

Détail du produit anti-Kallikrein 5 anticorps

Épitope: AA 36-177

Fonction: Kallikrein 5 Antibody / KLK5

Purification: Protein A/G affinity

Immunogène: A recombinant fragment of human KLK5 protein (within amino acids 36-177) was used as the immunogen for the Kallikrein 5 antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the Kallikrein 5 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Kallikrein 5 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur Kallikrein 5

Antigène: Kallikrein 5 (KLK5)

Autre désignation: Kallikrein 5

Sujet: Kallikreins (KLKs) belong to the serine protease family of proteolytic enzymes. Human pancreatic/renal KLK encodes for the KLK1 enzyme, which is involved in post-translational processing of polypeptide precursors. The function of the other members of KLK gene family is still currently unknown, but evidence suggests that many KLKs are implicated in carcinogenesis. The human KLK gene family consists of 15 serine proteases. The human KLK genes are clustered on chromosome 19q13. Unlike other kalllikreins, the KLK4-15 encoded proteases are less related and do not contain a conventional KLK loop. Clusters of genes exhibit high prostatic (KLK2-4, KLK15) or pancreatic (KLK6-13) expression. KLK2 is also known as glandular kallikrein 2, tissue kallikrein, or HGK-1 and KLK3 is known as prostate-specific antigen (PSA). Both KLK2 and KLK3 have important applications in prostate cancer and breast cancer diagnostics. Many of the KLKs are regulated by steroid hormones and a few of them, specifically KLK3, KLK6 and KLK10, are known to be downregulated in breast and other cancers. KLK5 expression is abundant in skin, mammary gland and testis.

UniProt: Q9Y337

Pathways: Système du Complément, Regulation of G-Protein Coupled Receptor Protein Signaling