MDM4-binding Protein anticorps (AA 8-490)

N° du produit ABIN7876836

L’anticorps anti-MDM4-binding Protein Polyclonal Lapin est utilisé pour la détection de MDM4-binding Protein dans des échantillons de Humain. Il a été validé pour WB et ELISA.

Aperçu rapide pour MDM4-binding Protein anticorps (AA 8-490) (ABIN7876836)

Antigène: MDM4-binding Protein (MDM4) (Mdm4-binding Protein (MDM4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MDM4-binding Protein est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-MDM4-binding Protein anticorps

Épitope: AA 8-490

Fonction: MDMX Antibody / MDM4

Purification: Antigen affinity purified

Immunogène: An E.coli-derived human recombinant protein (A8-A490) was used as the immunogen for the MDMX antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the MDMX antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the MDMX antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur MDM4-binding Protein

Antigène: MDM4-binding Protein (MDM4) (Mdm4-binding Protein (MDM4))

Autre désignation: MDMX

Sujet: Protein Mdm4/Mdmx is a protein that in humans is encoded by the MDM4 gene. This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

UniProt: O15151

Pathways: Cycle Cellulaire