OGG1 anticorps (full length)

N° du produit ABIN7877599

Cet anticorps anti-OGG1 Monoclonal Souris (Clone CPTC-OGG1-1) (ABIN7877599) détecte spécifiquement OGG1 dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour OGG1 anticorps (full length) (ABIN7877599)

Antigène: OGG1 (8-Oxoguanine DNA Glycosylase (OGG1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp OGG1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CPTC-OGG1-1

Détail du produit anti-OGG1 anticorps

Épitope: full length

Fonction: OGG1 Antibody / 8-Oxoguanine DNA Glycosylase

Purification: Protein G affinity chromatography

Immunogène: A recombinant full-length human protein was used as the immunogen for this OGG1 antibody.

Isotype: IgG2c, kappa

Information d'application

Indications d'application: Optimal dilution of the OGG1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the OGG1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur OGG1

Antigène: OGG1 (8-Oxoguanine DNA Glycosylase (OGG1))

Autre désignation: OGG1

Sujet: 8-oxoguanine (8-oxoG), an oxidized form of guanine, is produced by reactive oxygen species in both DNA and nucleotide pools during normal aging. Accumulation of 8-oxoG increases the occurrence of A:T to C:G or G:C to T:A transversionmutations, because 8-oxoG forms a stable basepair with adenine as well as with cytosine. OGG1 (for 8-oxoG DNA glycosylase), also designated MMH, is a DNA repair enzyme that corrects these mutations. Inactivation of the OGG1 gene leads to a mutator phenotype, characterized by the increase in G:C to T:A transversions. The OGG1 gene encodes eight isoforms (OGG1A-C, OGG2A-E) which result from alternative splicing of a single messenger RNA. The OGG1A splice variant is the most prevalent form and localizes to the nucleus, whereas the OGG2A splice variant is targeted to the mitochondria. Guanine is the main target for reactive oxygen species in DNA, and 8-oxoguanine is the most frequent base lesion. Therefore, formation of 8-oxoguanine is an important biomarker of oxidative damage to DNA. It is primarily repaired by the DNA glycosylase OGG1. Furthermore, defects in OGG1 may be a cause of renal cell carcinoma.

UniProt: O15527

Pathways: Réparation de l'ADN