STAT5B anticorps (full length)

N° du produit ABIN7879041

L’anticorps anti-STAT5B Monoclonal Souris est utilisé pour la détection de STAT5B dans des échantillons de Humain. Il a été validé pour ELISA.

Aperçu rapide pour STAT5B anticorps (full length) (ABIN7879041)

Antigène: STAT5B (Signal Transducer and Activator of Transcription 5B (STAT5B))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp STAT5B est non-conjugé

Application: ELISA

Classe de qualité: Carrier-free

Clone: STAT5B-2657

Détail du produit anti-STAT5B anticorps

Épitope: full length

Fonction: STAT5b Antibody (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogène: A recombinant full-length human STAT5B protein was used as the immunogen for this STAT5b antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the STAT5b antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the STAT5b antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur STAT5B

Antigène: STAT5B (Signal Transducer and Activator of Transcription 5B (STAT5B))

Autre désignation: STAT5b

Sujet: Signal transducer and activator of transcription 5A (Stat5a) and Stat5b, which share 96 % homology, undergo receptor tyrosine kinase or G protein-coupled receptor-dependent phosphorylation in response to cytokines or growth factors, and then form homo- or heterodimers that translocate to the nucleus, where they initiate transcription. Activation of Stat5a via IL-2, IL-3, IL-7/ GM-CSF, erythropoietin, thrombopoietin and growth hormones influences proliferation, differentiation and apoptosis in lymphohematopoietic cells. Phosphorylation of Stat5a at Ser127/Ser128 and Ser779 are contigent on ErbB-4-mediated activation of Stat5a. Activation of Stat5b via IL-2, IL-4, CSF-1 and growth hormones influences TCR signaling, apoptosis, adult mammary gland development and sexual dimorphism of liver gene expression. Stat5b is the major liver-expressed Stat5 form that has been shown to fuse with the retinoic acid receptor a gene in acute promyelocytic leukemias (APLL). Stat5a/b null mice have severely impaired lymphoid development and differentiation.

UniProt: P51692

Pathways: Signalistation JAK/STAT, Signalisation RTK, Response to Growth Hormone Stimulus, C21-Steroid Hormone Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Activated T Cell Proliferation