ERN1 anticorps (pSer724)

N° du produit ABIN7879768

Cet anticorps anti-ERN1 Monoclonal Lapin (Clone EGH-5) (ABIN7879768) détecte spécifiquement ERN1 dans WB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour ERN1 anticorps (pSer724) (ABIN7879768)

Antigène: ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp ERN1 est non-conjugé

Application: Western Blotting (WB)

Clone: EGH-5

Détail du produit anti-ERN1 anticorps

Épitope: pSer724

Fonction: Phospho-IRE1 Antibody (pS724)

Purification: Affinity purified

Immunogène: A synthetic peptide specific to human IRE1 / ERN1 (surrounding pS724) was used as the immunogen for the phospho-IRE1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the phospho-IRE1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the phospho-IRE1 antibody at -20oC.

Détails sur ERN1

Antigène: ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1))

Autre désignation: IRE1

Sujet: IRE1 is a serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR). In unstressed cells, the ER luminal domain is maintained in its inactive monomeric state by binding to the ER chaperone HSPA5/BiP. Accumulation of misfolded protein in the ER causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity. [UniProt]

UniProt: O75460

Pathways: ER-Nucleus Signaling, Unfolded Protein Response