Recombinant BRAF anticorps

N° du produit ABIN7880046

L’anticorps anti-BRAF Monoclonal Lapin est utilisé pour la détection de BRAF dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour Recombinant BRAF anticorps (ABIN7880046)

Antigène: BRAF (B-Raf proto-oncogene, serine/threonine kinase (BRAF))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp BRAF est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: BRAF-V600E-13276R

Détail du produit anti-BRAF anticorps

Fonction: Recombinant BRAF V600E Antibody

Purification: Protein A affinity

Immunogène: A recombinant fragment specific to human BRAF V600E mutant protein was used as the immunogen for the recombinant BRAF V600E antibody.

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal dilution of the recombinant BRAF V600E antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the recombinant BRAF V600E antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur BRAF

Antigène: BRAF (B-Raf proto-oncogene, serine/threonine kinase (BRAF))

Autre désignation: BRAF V600E

Sujet: The BRAF gene encodes a protein that is part of the RAS-RAF-MEK-ERK signaling pathway, which regulates cell division and proliferation. The V600E mutation in the BRAF gene leads to the production of a constitutively active BRAF protein, resulting in uncontrolled cell growth and division. Identifying the presence of this mutation is crucial for diagnosing and guiding the treatment of certain cancers. The BRAF (V600E) antibody is used in immunohistochemistry to detect the presence of a specific mutation in the BRAF gene known as V600E. This mutation is commonly associated with various cancers, including melanoma, colorectal cancer, and certain types of thyroid cancer, lung cancer, and Hairy cell leukemia. The BRAF (V600E) antibody specifically binds to the mutated BRAF protein, allowing pathologists to detect the mutation in cancer tissue. Immunohistochemistry using this antibody is often employed in the evaluation of tumor specimens to aid in the diagnosis and classification of cancers.

UniProt: P15056

Pathways: Signalisation MAPK, Signalisation RTK, Neurotrophin Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Hepatitis C, Autophagy