Recombinant LFNG anticorps

N° du produit ABIN7881470

Cet anticorps anti-LFNG Monoclonal Lapin (Clone 31L39) (ABIN7881470) détecte spécifiquement LFNG dans WB, IF et ICC. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Recombinant LFNG anticorps (ABIN7881470)

Antigène: LFNG (LFNG O-Fucosylpeptide 3-beta-N-Acetylglucosaminyltransferase (LFNG))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp LFNG est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: 31L39

Détail du produit anti-LFNG anticorps

Fonction: LFNG Antibody / Lunatic Fringe

Purification: Affinity-chromatography

Immunogène: A synthesized peptide derived from human Lunatic Fringe was used as the immunogen for the LFNG antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the LFNG antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the LFNG antibody at -20oC.

Détails sur LFNG

Antigène: LFNG (LFNG O-Fucosylpeptide 3-beta-N-Acetylglucosaminyltransferase (LFNG))

Autre désignation: LFNG

Sujet: LFNG antibody detects lunatic fringe, a glycosyltransferase that modifies Notch receptors and regulates Notch signaling pathways. LFNG belongs to the fringe family of glycosyltransferases, which add N-acetylglucosamine residues to O-fucose on epidermal growth factor-like repeats of Notch. This modification alters ligand binding specificity and modulates signaling outcomes critical for development and tissue homeostasis.

Research using LFNG antibody has highlighted the protein's role in embryogenesis. LFNG is required for somitogenesis, the process that establishes segmented structures in the developing embryo. Loss of LFNG function leads to defects in somitic patterning and skeletal abnormalities, demonstrating its importance in developmental timing. Beyond embryonic segmentation, LFNG also contributes to hematopoiesis, vascular development, and neural differentiation by fine-tuning Notch signaling activity.

Dysregulation of LFNG has been implicated in cancer and congenital disorders. Aberrant expression of LFNG can lead to uncontrolled Notch signaling, a hallmark of various malignancies including breast cancer and T-cell acute lymphoblastic leukemia. Reduced LFNG activity may also contribute to congenital scoliosis and vertebral malformations. Understanding how LFNG modifies Notch receptors provides insights into therapeutic targeting of developmental and cancer-related pathways.

Antibodies against LFNG are validated for western blot, immunohistochemistry, and immunofluorescence. These tools enable researchers to study expression patterns in embryonic and adult tissues, as well as to evaluate changes in Notch pathway regulation. Clone-based antibodies ensure reliable detection of LFNG across experimental conditions.

NSJ Bioreagents provides this LFNG antibody for developmental biology, cancer, and signaling research.

UniProt: Q8NES3

Pathways: Signalisation Notch