PFKFB3 anticorps (pSer467) (Cy5)

N° du produit ABIN744732

Détail du produit anti-PFKFB3 anticorps (Cy5)

Antigène: PFKFB3 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3))

Épitope: pSer467

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PFKFB3 est conjugé à/à la Cy5

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Specificité: This phosphorylated site is homologous to that of Ser467 in Mouse and Ser496 in Rat.

Réactivité croisée: Humain, Souris, Rat

Homologie: Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human PFK2 around the phosphorylation site of Ser467

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur PFKFB3

Antigène: PFKFB3 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3))

Autre désignation: PFK2 (PFKFB3 Produits)

Synonymes: anticorps IPFK2, anticorps PFK2, anticorps E330010H22Rik, anticorps iPFK-2, anticorps uPFK-2, anticorps PFKFB3, anticorps zgc:73257, anticorps wu:fc31e01, anticorps 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3, anticorps 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 S homeolog, anticorps PFKFB3, anticorps Pfkfb3, anticorps pfkfb3.S, anticorps pfkfb3, anticorps PTRG_09894, anticorps Tsp_06710

Sujet:

Synonyms: PFK2, IPFK2, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3, 6PF-2-K/Fru-2,6-P2ase 3, PFK/FBPase 3, 6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme, Renal carcinoma antigen NY-REN-56, iPFK-2, PFKFB3

Background: 6 Phosphofructo 2 Kinase plays a role in the synthesis and degradation of fructose 2,6-bisphosphate. Fructose-2,6-bisphosphate acts as an allosteric regulator of 6-phosphofructo-1-kinase (PFK1), which catalyses a key step in the glycoytic pathway. Glycolytic flux is key to tumour growth, and small molecule inhibition of 6 Phosphofructo 2 Kinase suppresses both glycolytic flux and tumour growth. Several lines of evidence suggest that 6 Phosphofructo 2 Kinase is also involved in obesity.

ID gène: 5209

UniProt: Q16875

Pathways: AMPK Signaling, Regulation of Carbohydrate Metabolic Process