ROR2 anticorps

N° du produit ABIN7882146

Cet anticorps Souris Monoclonal détecte spécifiquement ROR2 dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour ROR2 anticorps (ABIN7882146)

Antigène: ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ROR2 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: ROR2-1911

Détail du produit anti-ROR2 anticorps

Fonction: ROR2 Antibody

Purification: Protein G affinity chromatography

Immunogène: Cultured human keratinocytes were used as the immunogen for this ROR2 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the ROR2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the ROR2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur ROR2

Antigène: ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2))

Autre désignation: ROR2

Sujet: ROR2 (receptor tyrosine kinase-like orphan receptor 2), also known as neurotrophic tyrosine kinase receptor-related 2 (NTRKR2), is a single pass transmembrane tyrosine-protein kinase receptor. It contains a cytoplasmic tyrosine kinase domain, distally located serine-threonine-rich domains, an extracellular immunoglobulin-like domain, a cysteine-rich domain and a kringle domain. ROR2 is important for skeletal and endocrine development and is required for cartilage and growth plate development. It promotes the differentiation of osteoblasts and plays an important role in the early formation of chondrocytes. ROR2 sequesters and associates with Dlxin-1 affecting the transcriptional function of Msx-2. ROR2 also interacts with canoncial Wnt-1 and Wnt-3, regulating their signaling pathways. Defects in ROR2 can result in the autosomal dominant skeletal disorder, brachydactyly type B1, or the autosomal recessive skeletal disorder, Robinow syndrome.

UniProt: Q01974

Pathways: Signalisation RTK, Signalisation WNT