Prokineticin Receptor 1 anticorps (Extracellular, N-Term)

N° du produit ABIN7885321

L’anticorps anti-Prokineticin Receptor 1 Polyclonal Lapin est utilisé pour la détection de Prokineticin Receptor 1 dans des échantillons de Souris et Rat. Il a été validé pour WB, IHC, IF, FACS et LCI.

Aperçu rapide pour Prokineticin Receptor 1 anticorps (Extracellular, N-Term) (ABIN7885321)

Antigène: Prokineticin Receptor 1 (PROKR1)

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Prokineticin Receptor 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Classe de qualité: Carrier-free

Détail du produit anti-Prokineticin Receptor 1 anticorps

Épitope: AA 10-24, Extracellular, N-Term

Fonction: A Rabbit Polyclonal Antibody to Prokineticin Receptor 1

Homologie: Mouse - 12,15 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)ENTTNTFTDFFSARD, corresponding to amino acid residues 10-24 of rat PROKR1

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:100

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7236609)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Prokineticin Receptor 1

Antigène: Prokineticin Receptor 1 (PROKR1)

Autre désignation: PROKR1

Sujet:

Synonyms: PROKR1, PKR1, G-protein coupled receptor 73, Gpr73, Gpr73a, G-protein coupled receptor ZAQ

Description: The Prokineticins (PK1 and PK2) are a pair of cysteine-rich secreted peptides with broad physiological functions including gastrointestinal motility, angiogenesis, hematopoiesis and circadian rhythms regulation.The biological effects of PK1 and PK2 are mediated by two highly homologous receptors termed Prokineticin receptor 1 (PKR1) and Prokineticin receptor 2 (PKR2) that belong to the 7-transmembrane domain, G-protein coupled receptor (GPCR) superfamily. Both PK ligands activate the two PK receptors with similar potency.1PKR1 receptors couple to Gq/G11 proteins leading to phospholipase C activation, inositol phosphate production and calcium mobilization. In addition, activation of the mitogen-activated protein kinase (MAPK) pathways has also been described.1PKR1 is broadly distributed throughout peripheral tissues including the intestinal tract, testis, uterus, lung and peripheral blood leukocytes. In addition, the receptor is expressed in the brain, particularly in olfactory regions, as well as in dorsal root ganglion (DRG) neurons.The physiological function of PKR1 is still being elucidated, however, evidence suggest that the receptor has an important role in pain perception through its ability to stimulate the TRPV1 ion channel in DRG neurons.2In addition, a role for PKR1 in the control of the inflammatory response through regulation of macrophage chemotaxis and cytokine production has also been demonstrated.3

ID gène: 192648

UniProt: Q8R416

Pathways: Signalisation Hedgehog, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma