Tetraspanin 7 anticorps (Extracellular, Loop 2)

N° du produit ABIN7885573

L’anticorps anti-Tetraspanin 7 Polyclonal Lapin est utilisé pour la détection de Tetraspanin 7 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, FACS, IHC et LCI.

Aperçu rapide pour Tetraspanin 7 anticorps (Extracellular, Loop 2) (ABIN7885573)

Antigène: Tetraspanin 7 (TSPAN7)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Tetraspanin 7 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC), Live Cell Imaging (LCI)

Classe de qualité: Carrier-free

Détail du produit anti-Tetraspanin 7 anticorps

Épitope: AA 155-169, Extracellular, Loop 2

Fonction: A Rabbit Polyclonal Antibody to Tetraspanin 7 (extracellular)

Homologie: Mouse - 15 out of 16 amino acid residues identical, rat - 14 out of 16 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)DWENTDWFKETKNQS, corresponding to amino acid residues 155 - 169 of human Tetraspanin-3

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:400-1:500

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:300

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7237381)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Tetraspanin 7

Antigène: Tetraspanin 7 (TSPAN7)

Autre désignation: TSPAN7

Sujet:

Synonyms: TSPAN7, Transmembrane 4 Superfamily Member 2, TM4SF2, T-Cell Acute Lymphoblastic Leukemia-Associated Antigen 1, TALLA-1, Cell Surface Glycoprotein A15, A15, CD231.

Description: Tetraspanins (Tspans) are a family of four-span transmembrane proteins, known as plasma membrane "master organizers." They form Tspan-enriched microdomains (TEMs or TERMs) through lateral association with one another and other membrane proteins.1Tetraspanins are characterized by four transmembrane domains, two extracellular loops: one small extracellular loop (SEL or EC1) and one larger extracellular loop (LEL or EC2), a short intracellular loop, and two short intracellular tails.1Teatraspanin 7 (TSPAN7) is highly expressed in the brain and was first described as a candidate gene for X-linked intellectual disability, probably through the modulation of surface expression of AMPA and dopamine receptors.2Tetraspanin 7 also has a key role in controlling pancreatic β-cell Ca2+ handling and defining the set-point of insulin secretion through modulation of L-type Cav1.2 and Cav1.3 channels. Furthermore, it has been identified as a target for autoantibodies in Type I diabetes. 3In addition, Tetraspanin 7 is involved in the regulation of HIV virus entry into dendritic cells and several types of cancer progression. 2

ID gène: 7102

UniProt: P41732