Retinoblastoma Binding Protein 8 anticorps (AA 620-897)

N° du produit ABIN7938099

Cet anticorps anti-Retinoblastoma Binding Protein 8 Monoclonal Souris (Clone 14-1) (ABIN7938099) détecte spécifiquement Retinoblastoma Binding Protein 8 dans WB, IP, IF, ICC et ChIP. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Retinoblastoma Binding Protein 8 anticorps (AA 620-897) (ABIN7938099)

Antigène: Retinoblastoma Binding Protein 8 (RBBP8)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Retinoblastoma Binding Protein 8 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC), Chromatin Immunoprecipitation (ChIP)

Clone: 14-1

Détail du produit anti-Retinoblastoma Binding Protein 8 anticorps

Épitope: AA 620-897

Fonction: CtIP antibody (mAb) (Clone 14-1)

Purification: Protein A Chromatography

Immunogène: This CtIP antibody was raised against a recombinant protein corresponding to amino acid residues 620-897 of human CtIP.

Isotype: IgG1

Information d'application

Indications d'application: WB: 1 - 2 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Stock: -20 °C

Stockage commentaire: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Date de péremption: 24 months

Détails sur Retinoblastoma Binding Protein 8

Antigène: Retinoblastoma Binding Protein 8 (RBBP8)

Autre désignation: CtIP

Sujet:

Background_Plain: CtIP (CTBP interacting protein, RBBP8, RIM, COM1) is a transcriptional regulator and tumor suppressor first identified through its interaction with CTBP (C-Terminal Binding Protein). CtIP binds to the Rb protein and serves as a transcriptional repressor, through recruitment of CtBP and also by interaction with general transcription factors TFIID and TFIIB. CtIP also interacts with Rb-related protein p130 and Ikaros, a master regulator in lymphocyte development. CtIP is phosphorylated upon DNA damage (likely by ATM and/or ATR), interacts with BRCA1 and plays a critical role in facilitating DNA damage repair. Mutations that abolish the interaction between CtIP and BRCA1 result in loss of cell cycle control leading to the development of cancer.

Aliases: RBBP8, RIM, COM1, JWDS, SAE2, SCKL2

Poids moléculaire: 120 kDa

NCBI Accession: NP_002885

Pathways: Cycle Cellulaire, Réparation de l'ADN