AIM2 anticorps (AA 136-354) (HRP)

N° du produit ABIN7965402

Cet anticorps anti-AIM2 Polyclonal Lapin conjugué à HRP (ABIN7965402) détecte spécifiquement AIM2 dans WB, ELISA et IHC. L’anticorps est réactif avec des échantillons de Souris.

Aperçu rapide pour AIM2 anticorps (AA 136-354) (HRP) (ABIN7965402)

Antigène: AIM2 (Absent in Melanoma 2 (AIM2))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AIM2 est conjugé à/à la HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-AIM2 anticorps (HRP)

Épitope: AA 136-354

Fonction: Anti-Aim2 Antibody HRP Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived mouse Aim2 recombinant protein (Position: Q136-E354).

Isotype: IgG

Information d'application

Indications d'application: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur AIM2

Antigène: AIM2 (Absent in Melanoma 2 (AIM2))

Autre désignation: Aim2

Sujet:

Background: Interferon-inducible protein AIM2,also known asabsent in melanoma 2or simplyAIM2,is aproteinthat in humans is encoded by theAIM2gene. It is mapped to 1q22. AIM2 is a member of theIfi202/IFI16family. It plays a putative role in tumorigenic reversion and may control cell proliferation.Interferon-gammainduces expression of AIM2. Though there has been virtually no biochemistry performed, a model based on cell-based or in vivo experiments has led to the current model of how AIM2 triggers the inflammasome. The C-terminal HIN domain binds double stranded DNA(either viral, bacterial, or even host) and acts as a cytosolic dsDNA sensor. This leads to the oligomerization of the inflammasome complex. The N-terminal pyrin domain of AIM2 interacts with the pyrin domain of another proteinASC(or Apoptosis-associated Speck-like protein containing a caspase activation and recruitment domain). ASC also contains aCARD domain(caspase activation and recruitment domain), that recruits procaspase-1 to the complex. This leads to the autoactivation ofcaspase-1, an enzyme that processes proinflammatorycytokines(IL-1bandIL-18).

Gene Full Name: absent in melanoma 2

ID gène: 383619

UniProt: Q91VJ1

Pathways: Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome