Caspase 12 anticorps (N-Term) (Fluoro550)

N° du produit ABIN7975198

L’anticorps anti-Caspase 12 Polyclonal Lapin est utilisé pour la détection de Caspase 12 dans des échantillons de Humain et Rat. Il a été validé pour FACS.

Aperçu rapide pour Caspase 12 anticorps (N-Term) (Fluoro550) (ABIN7975198)

Antigène: Caspase 12 (CASP12) (Caspase 12 (Gene/pseudogene) (CASP12))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Caspase 12 est conjugé à/à la Fluoro550

Application: Flow Cytometry (FACS)

Détail du produit anti-Caspase 12 anticorps (Fluoro550)

Épitope: N-Term

Fonction: Anti-Caspase-12/CASP12 Antibody Fluoro550 Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of human Caspase-12.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur Caspase 12

Antigène: Caspase 12 (CASP12) (Caspase 12 (Gene/pseudogene) (CASP12))

Autre désignation: CASP12

Sujet:

Background: Caspase 12 is an enzyme known as a cysteine protease. It belongs to a family of enzymes called caspases that cleave their substrates at C-terminal aspartic acid residues. The CASP12 gene was mapped to chromosome 11q22.3. Csp12L attenuates the inflammatory and innate immune response to endotoxins and in doing so may constitute a risk factor for developing sepsis. The estrogen-mediated inhibition of CSP12L expression is a built-in mechanism that has evolved to protect females from infection by favoring a more robust inflammatory response to pathogens, perhaps notably in childbirth.

Gene Full Name: caspase 12 (gene/pseudogene)

Sequence Similarities: Belongs to the peptidase C14A family.

ID gène: 100506742

UniProt: Q6UXS9

Pathways: Apoptose, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response