LAT anticorps (AA 29-217) (APC)

N° du produit ABIN8006247

L’anticorps anti-LAT Polyclonal Lapin est utilisé pour la détection de LAT dans des échantillons de Souris et Rat. Il a été validé pour FACS.

Aperçu rapide pour LAT anticorps (AA 29-217) (APC) (ABIN8006247)

Antigène: LAT (Linker For Activation of T Cells (LAT))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LAT est conjugé à/à la APC

Application: Flow Cytometry (FACS)

Détail du produit anti-LAT anticorps (APC)

Épitope: AA 29-217

Fonction: Anti-Lat Antibody APC Conjugated

Réactivité croisée (Details): No cross reactivity with other proteins.

Homologie: Mouse Lat shares 68.4%,93.1% amino acid (aa) sequence identity with human,rat Lat,respectively.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived mouse Lat recombinant protein (Position: R29-E217). Mouse Lat shares 68.4% and 93.1% amino acid (aa) sequence identity with human and rat Lat, respectively.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur LAT

Antigène: LAT (Linker For Activation of T Cells (LAT))

Autre désignation: Lat

Sujet:

Background: The Linker for activation of T cells, also known as linker of activated T cells or LAT, is a protein involved in the T-cell antigen receptor signal transduction pathway which in humans is encoded by the LAT gene. The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene Full Name: linker for activation of T cells

ID gène: 16797

UniProt: O54957

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway