Meprin B anticorps (AA 73-489) (Biotin)

N° du produit ABIN8009144

Cet anticorps Lapin Polyclonal détecte spécifiquement Meprin B dans WB, IHC et ELISA. Il présente une réactivité avec des échantillons de Rat, Humain et Souris.

Aperçu rapide pour Meprin B anticorps (AA 73-489) (Biotin) (ABIN8009144)

Antigène: Meprin B (MEP1B) (Meprin A, beta (MEP1B))

Reactivité: Rat, Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Meprin B est conjugé à/à la Biotin

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-Meprin B anticorps (Biotin)

Épitope: AA 73-489

Fonction: Anti-MEP1B Antibody Biotin Conjugated

Homologie: Human MEP1B shares 82.3%,81.5% amino acid (aa) sequence identity with mouse,rat MEP1B,respectively.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human MEP1B recombinant protein (Position: H73-Q489). Human MEP1B shares 82.3% and 81.5% amino acid (aa) sequence identity with mouse and rat MEP1B, respectively.

Isotype: IgG

Information d'application

Indications d'application: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur Meprin B

Antigène: Meprin B (MEP1B) (Meprin A, beta (MEP1B))

Autre désignation: MEP1B

Sujet:

Background: Meprin A subunit beta is a protein that in humans is encoded by the MEP1B gene. Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine.

Gene Full Name: meprin A subunit beta

ID gène: 4225

UniProt: Q16820