MUS81 anticorps (AA 6-545) (Fluoro488)

N° du produit ABIN8012073

L’anticorps anti-MUS81 Polyclonal Lapin est utilisé pour la détection de MUS81 dans des échantillons de Humain et Rat. Il a été validé pour FACS.

Aperçu rapide pour MUS81 anticorps (AA 6-545) (Fluoro488) (ABIN8012073)

Antigène: MUS81 (MUS81 Endonuclease Homolog (MUS81))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MUS81 est conjugé à/à la Fluoro488

Application: Flow Cytometry (FACS)

Détail du produit anti-MUS81 anticorps (Fluoro488)

Épitope: AA 6-545

Fonction: Anti-MUS81 Antibody Fluoro488 Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human MUS81 recombinant protein (Position: R6-C545).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur MUS81

Antigène: MUS81 (MUS81 Endonuclease Homolog (MUS81))

Autre désignation: MUS81

Sujet:

Background: Crossover junction endonuclease MUS81 is an enzyme that in humans is encoded by the MUS81 gene. This gene encodes a structure-specific endonuclease which belongs to the XPF/MUS81 endonuclease family and plays a critical role in the resolution of recombination intermediates during DNA repair after inter-strand cross-links, replication fork collapse, and DNA double-strand breaks. The encoded protein associates with one of two closely related essential meiotic endonuclease proteins (EME1 or EME2) to form a complex that processes DNA secondary structures. It contains an N-terminal DEAH helicase domain, an excision repair cross complementation group 4 (ERCC4) endonuclease domain, and two tandem C-terminal helix-hairpin-helix domains. Mice with a homozygous knockout of the orthologous gene have significant meiotic defects including the failure to repair a subset of DNA double strand breaks.

Gene Full Name: MUS81 structure-specific endonuclease subunit

ID gène: 80198

UniProt: Q96NY9

Pathways: Réparation de l'ADN