Retinoblastoma Binding Protein 8 anticorps (AA 307-702) (HRP)

N° du produit ABIN8031825

L’anticorps anti-Retinoblastoma Binding Protein 8 Polyclonal Lapin est utilisé pour la détection de Retinoblastoma Binding Protein 8 dans des échantillons de Humain et Souris. Il a été validé pour ELISA, WB et IHC.

Aperçu rapide pour Retinoblastoma Binding Protein 8 anticorps (AA 307-702) (HRP) (ABIN8031825)

Antigène: Retinoblastoma Binding Protein 8 (RBBP8)

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Retinoblastoma Binding Protein 8 est conjugé à/à la HRP

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Retinoblastoma Binding Protein 8 anticorps (HRP)

Épitope: AA 307-702

Fonction: Anti-RBBP8 Antibody HRP Conjugated

Réactivité croisée (Details): No cross reactivity with other proteins.

Homologie: Human RBBP8 shares 68.9%,66.7% amino acid (aa) sequence identity with mouse,rat RBBP8,respectively.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human RBBP8 recombinant protein (Position: R307-K702). Human RBBP8 shares 68.9% and 66.7% amino acid (aa) sequence identity with mouse and rat RBBP8, respectively.

Isotype: IgG

Information d'application

Indications d'application: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur Retinoblastoma Binding Protein 8

Antigène: Retinoblastoma Binding Protein 8 (RBBP8)

Autre désignation: RBBP8

Sujet:

Background: Retinoblastoma-binding protein 8 is a protein that in humans is encoded by the RBBP8 gene. The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind ly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.

Gene Full Name: RB binding protein 8, endonuclease

ID gène: 5932

UniProt: Q99708

Pathways: Cycle Cellulaire, Réparation de l'ADN