Serotonin Receptor 1A anticorps (C-Term)

N° du produit ABIN8036214

L’anticorps anti-Serotonin Receptor 1A Polyclonal Lapin est utilisé pour la détection de Serotonin Receptor 1A dans des échantillons de Humain et Rat. Il a été validé pour WB et IHC.

Aperçu rapide pour Serotonin Receptor 1A anticorps (C-Term) (ABIN8036214)

Antigène: Serotonin Receptor 1A (HTR1A)

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Serotonin Receptor 1A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Classe de qualité: Carrier-free

Détail du produit anti-Serotonin Receptor 1A anticorps

Épitope: C-Term

Fonction: Anti-5HT1A Receptor/HTR1A Antibody

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: different from the related rat,mouse sequences by one amino acid.

Attributs du produit: Anti-5HT1A Receptor/HTR1A Antibody. Tested in IHC, WB applications. This antibody reacts with Human, Rat.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human 5HT1A Receptor, different from the related rat and mouse sequences by one amino acid.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.1-0.5 μg/mL, Human, Rat Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human, Rat

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur Serotonin Receptor 1A

Antigène: Serotonin Receptor 1A (HTR1A)

Autre désignation: HTR1A

Sujet:

Background: HTR1A (5-HYDROXYTRYPTAMINE RECEPTOR 1A), also called SEROTONIN 5-HT-1A RECEPTOR or BETA-2-ADRENERGIC RECEPTOR-LIKE PROTEIN G-21, is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin. It is a G protein-coupled receptor (GPCR) that is coupled to Gi/Go and mediates inhibitory neurotransmission. HTR1A denotes the human gene encoding for the receptor.The HTR1A gene is located at 5q12.3. The decreases in 5-HT-1A receptor densities correlated with decreased glucose utilization as measured by PET scan. Activation of 5-HT-1A receptors has been demonstrated to impair cognition, learning, and memory by inhibiting the release of glutamate and acetylcholine in various areas of the brain. 5-HT-1A receptors in the dorsal raphe nucleus are co-localized with neurokinin 1 (NK1) receptors and have been shown to inhibit the release of substance P, their endogenous ligand.

Gene Full Name: 5-hydroxytryptamine receptor 1A

Sequence Similarities: Belongs to the WD repeat BUB3 family.

Poids moléculaire: 46 kDa

ID gène: 3350

UniProt: P08908

Pathways: Signalistation JAK/STAT, Synaptic Membrane, Feeding Behaviour