TWIST1, TWIST2 (AA 75-160) anticorps (Cy5.5)

N° du produit ABIN754908

Détail du produit

Antigène: TWIST1, TWIST2

Épitope: AA 75-160

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cy5.5

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Specificité: This antibody will detect TWIST1 and TWIST2

Réactivité croisée: Humain

Homologie: Mouse,Rat,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human TWIST2

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: TWIST1, TWIST2

Autre désignation: TWIST1 and TWIST2

Synonymes: anticorps Twist, anticorps DERMO1, anticorps FFDD3, anticorps SETLSS, anticorps bHLHa39, anticorps AA960487, anticorps M-Twist, anticorps Pde, anticorps Ska10, anticorps Ska, anticorps bHLHa38, anticorps pdt, anticorps FDXP2, anticorps twist family bHLH transcription factor 1, anticorps twist family bHLH transcription factor 2, anticorps twist basic helix-loop-helix transcription factor 1, anticorps ferredoxin 1 pseudogene 2, anticorps Twist1, anticorps TWIST2, anticorps FDX1P2

Sujet:

Synonyms: TWIST, bHLHa38, Twist-related protein 1, Class A basic helix-loop-helix protein 38, H-twist, TWIST1, bHLHa39, Class A basic helix-loop-helix protein 39, Dermis expressed protein 1, Dermis-expressed protein 1, DERMO 1, Dermo-1, DERMO1, MGC117334, Twist 2, Twist homolog 2 Drosophila, Twist homolog 2, Twist related bHLH protein Dermo1, Twist related protein 2, Twist-related protein 2, Twist2, TWST2_HUMAN.

Background: TWIST1 and TWIST2 are basic helix-loop-helix transcriptional repressors that bind to E boxes in gene promoters, acting as master regulators in a variety of biological processes, including organogenesis, osteogenesis, cancer progression and hematopoietic cell development. Both TWIST1 and TWIST2 are found to act as Homodimers or Heterodimers with another bHLH protein. TWIST1 Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. TWIST1 also represses expression of proinflammatory cytokines such as TNFA and IL1B. TWIST2 inhibits transcriptional activation by MYOD1, MYOG, MEF2A, and MEF2C. Twist2 inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis.

ID gène: 7291, 117581

UniProt: Q15672, Q8WVJ9