GRK2 anticorps (pTyr86)

N° du produit ABIN8119627

Cet anticorps anti-GRK2 Polyclonal Lapin (ABIN8119627) détecte spécifiquement GRK2 dans WB, IHC et IF. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour GRK2 anticorps (pTyr86) (ABIN8119627)

Antigène: GRK2 (ADRBK1) (Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GRK2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-GRK2 anticorps

Épitope: pTyr86

Fonction: GRK2 (Phospho Tyr86) Antibody

Specificité: This antibody detects endogenous phospho levels of GRK2 (Phospho-Tyr86) at Human:Y86, Mouse:Y86, Rat:Y86

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogène: Synthesized peptide derived from human GRK2 (Phospho-Tyr86)

Isotype: IgG

Information d'application

Indications d'application: IHC 1:50-200, WB 1:500-2000. IF 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur GRK2

Antigène: GRK2 (ADRBK1) (Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))

Autre désignation: GRK2

Sujet:

Synonyms: Beta-adrenergic receptor kinase 1 (Beta-ARK-1, EC 2.7.11.15, G-protein coupled receptor kinase 2)

Background: The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008],

Gene Name: ADRBK1 BARK BARK1 GRK2

Protein Name: GRK2 (Phospho-Tyr86)

ID gène: 156

UniProt: P25098

Pathways: EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling