FOXO3 anticorps (acLys569)

N° du produit ABIN8121505

Cet anticorps anti-FOXO3 Polyclonal Lapin (ABIN8121505) détecte spécifiquement FOXO3 dans WB et ELISA. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour FOXO3 anticorps (acLys569) (ABIN8121505)

Antigène: FOXO3 (Forkhead Box O3 (FOXO3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FOXO3 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-FOXO3 anticorps

Épitope: acLys569

Fonction: FoxO3A (Acetyl Lys569) Antibody

Specificité: This antibody detects endogenous levels of Human,Mouse,Rat FoxO3A (Acetyl Lys569)

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogène: Synthesized peptide derived from human FoxO3A (Acetyl Lys569)

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-2000 ELISA 1:5000-20000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur FOXO3

Antigène: FOXO3 (Forkhead Box O3 (FOXO3))

Autre désignation: FoxO3A

Sujet:

Synonyms: Forkhead box protein O3 (AF6q21 protein, Forkhead in rhabdomyosarcoma-like 1)

Background: disease:A chromosomal aberration involving FOXO3 is found in secondary acute leukemias. Translocation t(6,11)(q21,q23) with MLL/HRX.,function:Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'.,PTM:In the presence of survival factors such as IGF-1, phosphorylated on Thr-32 and Ser-253 by AKT1/PKB. This phosphorylated form then interacts with 14-3-3 proteins and is retained in the cytoplasm. Survival factor withdrawal induces dephosphorylation and promotes translocation to the nucleus where the dephosphorylated protein induces transcription of target genes and triggers apoptosis. Although AKT1/PKB doesn't appear to phosphorylate Ser-315 directly, it may activate other kinases that trigger phosphorylation at this residue. Phosphorylated by STK4 on Ser-209 upon oxidative stress, which leads to dissociation from YWHAB/14-3-3-beta and nuclear translocation.,similarity:Contains 1 fork-head DNA-binding domain.,subcellular location:Translocates to the nucleus upon oxidative stress and in the absence of survival factors.,subunit:Interacts with YWHAB/14-3-3-beta and YWHAZ/14-3-3-zeta, which are required for cytosolic sequestration. Upon oxidative stress, interacts with STK4, which disrupts interaction with YWHAB/14-3-3-beta and leads to nuclear translocation.,tissue specificity:Ubiquitous.,

Gene Name: FOXO3 FKHRL1 FOXO3A

Protein Name: FoxO3A (Acetyl Lys569)

ID gène: 2309

UniProt: O43524

Pathways: Cycle Cellulaire, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis