LRP2 anticorps (AA 2890-2970)

N° du produit ABIN8122677

L’anticorps anti-LRP2 Polyclonal Lapin est utilisé pour la détection de LRP2 dans des échantillons de Humain, Souris et Rat. Il a été validé pour IHC et IF.

Aperçu rapide pour LRP2 anticorps (AA 2890-2970) (ABIN8122677)

Antigène: LRP2 (Low Density Lipoprotein Receptor-Related Protein 2 (LRP2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LRP2 est non-conjugé

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-LRP2 anticorps

Épitope: AA 2890-2970

Fonction: LRP2 Antibody

Specificité: LRP2 Polyclonal Antibody detects endogenous levels of protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from human protein . at AA range: 2890-2970

Isotype: IgG

Information d'application

Indications d'application: IHC 1:50-300. IF 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur LRP2

Antigène: LRP2 (Low Density Lipoprotein Receptor-Related Protein 2 (LRP2))

Autre désignation: LRP2

Sujet:

Background: The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling, extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of th

Gene Name: LRP2

Protein Name: Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin)

ID gène: 4036

UniProt: P98164

Pathways: Metabolism of Steroid Hormones and Vitamin D, Thyroid Hormone Synthesis, Hormone Transport