POLB anticorps (acLys72)

N° du produit ABIN8123855

Cet anticorps Lapin Polyclonal détecte spécifiquement POLB dans WB et ELISA. Il présente une réactivité avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour POLB anticorps (acLys72) (ABIN8123855)

Antigène: POLB (Polymerase (DNA Directed), beta (POLB))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp POLB est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-POLB anticorps

Épitope: acLys72

Fonction: DNA pol β (Acetyl Lys72) Antibody

Specificité: This antibody detects endogenous levels of Human,Mouse,Rat DNA pol β (Acetyl Lys72)

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogène: Synthesized peptide derived from human DNA pol beta (Acetyl Lys72)

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-2000 ELISA 1:5000-20000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur POLB

Antigène: POLB (Polymerase (DNA Directed), beta (POLB))

Autre désignation: DNA pol beta

Sujet:

Synonyms: DNA polymerase beta (EC 2.7.7.7, EC 4.2.99.-)

Background: catalytic activity:Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).,cofactor:Binds 2 magnesium ions per subunit.,domain:Residues 239-252 form a flexible loop which appears to affect the polymerase fidelity.,function:Repair polymerase. Conducts "gap-filling" DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.,PTM:Methylation by PRMT6 stimulates the polymerase activity by enhancing DNA binding and processivity.,similarity:Belongs to the DNA polymerase type-X family.,subunit:Monomer.,

Gene Name: POLB

Protein Name: DNA pol β (Acetyl Lys72)

ID gène: 5423

UniProt: P06746

Pathways: Réparation de l'ADN