NLRP4 anticorps (Center)

N° du produit ABIN783705

Cet anticorps anti-NLRP4 Polyclonal Lapin (ABIN783705) détecte spécifiquement NLRP4 dans WB et EIA. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour NLRP4 anticorps (Center) (ABIN783705)

Antigène: NLRP4 (NLR Family, Pyrin Domain Containing 4 (NLRP4))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NLRP4 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-NLRP4 anticorps

Épitope: Center

Specificité: This antibody detects NALP4 at Center.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse

Purification: Affinity chromatography purified via peptide column

Immunogène: 13 amino acid peptide near the center of human NALP4

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Détails sur NLRP4

Antigène: NLRP4 (NLR Family, Pyrin Domain Containing 4 (NLRP4))

Autre désignation: NALP4

Sujet: NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP4, also known as PYRIN-containing APAF1-like protein 4, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. In transfected 293 cells, NALP4 suppressed NF-kB induction by TNF-a and IL-1b, suggesting NALP4 operates at a point of convergence in these two signaling pathways. NALP4 also suppressed NF-kB induction resulting from overexpression of several adapter proteins and protein kinases involved in these pathways, including TRAF2, TRAF6, RIP, and IRAK2, as well as the IKK-a and IKK-b, suggesting that NALP4 is critical in modulating NF-kB activity.Synonyms: LRR and PYD domains-containing protein 4, NACHT, NLRP4, PAN2, PYPAF4, RNH2

ID gène: 147945

NCBI Accession: NP_604393

UniProt: Q96MN2

Pathways: Inflammasome