NLRP4 anticorps (Center)

N° du produit ABIN783705

Détail du produit anti-NLRP4 anticorps

Antigène: NLRP4 (NLR Family, Pyrin Domain Containing 4 (NLRP4))

Épitope: Center

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NLRP4 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody detects NALP4 at Center.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse

Purification: Affinity chromatography purified via peptide column

Immunogène: 13 amino acid peptide near the center of human NALP4

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Détails sur NLRP4

Antigène: NLRP4 (NLR Family, Pyrin Domain Containing 4 (NLRP4))

Autre désignation: NALP4 (NLRP4 Produits)

Synonymes: anticorps CLR19.5, anticorps CT58, anticorps NALP4, anticorps PAN2, anticorps PYPAF4, anticorps RNH2, anticorps Nalp4, anticorps Nlrp4e, anticorps RGD1563529, anticorps NLR family pyrin domain containing 4, anticorps NLR family, pyrin domain containing 4, anticorps NLRP4, anticorps Nlrp4

Sujet: NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP4, also known as PYRIN-containing APAF1-like protein 4, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. In transfected 293 cells, NALP4 suppressed NF-kB induction by TNF-a and IL-1b, suggesting NALP4 operates at a point of convergence in these two signaling pathways. NALP4 also suppressed NF-kB induction resulting from overexpression of several adapter proteins and protein kinases involved in these pathways, including TRAF2, TRAF6, RIP, and IRAK2, as well as the IKK-a and IKK-b, suggesting that NALP4 is critical in modulating NF-kB activity.Synonyms: LRR and PYD domains-containing protein 4, NACHT, NLRP4, PAN2, PYPAF4, RNH2

ID gène: 147945

NCBI Accession: NP_604393

UniProt: Q96MN2

Pathways: Inflammasome