GABRB3 anticorps (pSer408, pSer409)

N° du produit ABIN784601

Détail du produit anti-GABRB3 anticorps

Antigène: GABRB3 (gamma-aminobutyric Acid (GABA) A Receptor, beta 3 (GABRB3))

Épitope: pSer408, pSer409

Reactivité: Humain, Rat, Souris, Boeuf (Vache), Chien, Poulet, Poisson zèbre (Danio rerio), Non-Human Primate, Xenopus laevis

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GABRB3 est non-conjugé

Application: Western Blotting (WB)

Specificité: The antibody has been directly tested for reactivity in Western blots with rat tissue. Specific for the ~53k GABAA receptor beta-3 subunit phosphorylated at Ser408/409. Immunolabeling of the GABAA band is completely blocked by the phospho-peptide used as antigen but not by the corresponding dephospho-peptide.

Réactivité croisée (Details): Species reactivity (expected):Bovine, Canine, Chicken, Human, Mouse, non-Human primates, Xenopus and Zebrafish.
Species reactivity (tested):Rat.

Purification: Affinity Chromatography.

Immunogène: Phosphopeptide corresponding to amino acid residues surrounding the di-phospho- Ser408/409 of the Rat GABAA receptor, beta-3 subunit.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody undiluted (in aliquots) at -20 °C.

Détails sur GABRB3

Antigène: GABRB3 (gamma-aminobutyric Acid (GABA) A Receptor, beta 3 (GABRB3))

Autre désignation: GABRB3 (GABRB3 Produits)

Synonymes: anticorps GABRB3, anticorps eca5, anticorps LOC100230475, anticorps ECA5, anticorps A230092K12Rik, anticorps AW049585, anticorps Cp1, anticorps Gabrb-3, anticorps beta3, anticorps gamma-aminobutyric acid type A receptor beta3 subunit, anticorps gamma-aminobutyric acid (GABA) A receptor, beta 3, anticorps gamma-aminobutyric acid type A receptor beta 3 subunit, anticorps gamma-aminobutyric acid (GABA) A receptor, subunit beta 3, anticorps GABRB3, anticorps gabrb3, anticorps Gabrb3

Sujet: Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six Alpha's, four Beta's and four Gamma's, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990, Whiting et al., 1999, Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for Alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a Gamma-subunit is required for benzodiazepine modulation. Phosphorylation of Serine 408 and Serine 409 within the Beta-3 subunit have been shown to be critical for the functional modulation of Beta-3 containing recombinant receptors (Brandon et al., 2000).Synonyms: GABA A receptor subunit beta-3, GABRB-3, Gamma-aminobutyric acid receptor subunit beta-3

ID gène: 24922

NCBI Accession: NP_058761

Pathways: Sensory Perception of Sound