CHEK2 anticorps (AA 514-518)
Aperçu rapide pour CHEK2 anticorps (AA 514-518) (ABIN871613)
Antigène
Voir toutes CHEK2 AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
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Épitope
- AA 514-518
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Specificité
- The antibody detects endogenous levels of total Chk2 protein.
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Purification
- Affinity purified
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Immunogène
- Peptide sequence around AA 514-518 (Q-P-S-T-S) derived from Chk2 Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
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anti-Checkpoint Kinase 2 (CHEK2) (pThr387) antibody
CHEK2 Reactivité: Humain, Souris, Rat WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (AA 1-543) antibodyCHEK2 Reactivité: Humain WB, ELISA, IF, IHC (p) Hôte: Souris Monoclonal 4B7 unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (AA 1-543) antibodyCHEK2 Reactivité: Humain WB, IP Hôte: Lapin Polyclonal unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (pThr383) antibodyCHEK2 Reactivité: Humain, Souris, Rat WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (pSer516) antibodyCHEK2 Reactivité: Humain, Souris, Rat WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (pThr68) antibodyCHEK2 Reactivité: Humain, Souris, Rat WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
anti-Checkpoint Kinase 2 (CHEK2) antibodyCHEK2 Reactivité: Humain, Singe, Chien WB, IHC, IF, IHC (p), FACS Hôte: Souris Monoclonal 10G7 unconjugated
anti-Checkpoint Kinase 2 (CHEK2) antibodyCHEK2 Reactivité: Humain, Chien WB, IHC, IF, IHC (p), IP, FACS Hôte: Souris Monoclonal 5C4 unconjugated
anti-Checkpoint Kinase 2 (CHEK2) antibodyCHEK2 Reactivité: Humain, Chien WB, IHC, IHC (p), IP, FACS Hôte: Souris Monoclonal 2H5 unconjugated
anti-Checkpoint Kinase 2 (CHEK2) antibodyKD Validated CHEK2 Reactivité: Humain WB, IF (p), FACS Hôte: Lapin Monoclonal 23GB3460 unconjugated Recombinant Antibody
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Indications d'application
- Western blotting: 1:500-1:1000
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 mg/mL
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Buffer
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Stock
- 4 °C/-20 °C
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Stockage commentaire
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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- CHEK2 (Checkpoint Kinase 2 (CHEK2))
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Autre désignation
- Chk2
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Sujet
- The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation
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Poids moléculaire
- 62 kDa
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ID gène
- 11200
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NCBI Accession
- NP_001005
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UniProt
- O96017
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Pathways
- Signalisation p53, Apoptose, Cycle Cellulaire
Antigène
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