RING1 anticorps (AA 35-39)

N° du produit ABIN871729

Détail du produit anti-RING1 anticorps

Antigène: RING1 (Ring Finger Protein 1 (RING1))

Épitope: AA 35-39

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RING1 est non-conjugé

Application: Western Blotting (WB)

Specificité: The antibody detects endogenous level of total Ring1A protein.

Purification: Affinity purified

Immunogène: Peptide sequence around AA 35-39 ( I-A-V-S-P) derived from Human Ring1A. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.

Information d'application

Indications d'application: Western blotting: 1:500-1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Détails sur RING1

Antigène: RING1 (Ring Finger Protein 1 (RING1))

Autre désignation: Ring1A (RING1 Produits)

Synonymes: anticorps RING1A, anticorps RNF1, anticorps Ring1A, anticorps bap-1, anticorps bap1, anticorps ding, anticorps hipi3, anticorps ring1a, anticorps ring1b, anticorps ring2, anticorps rnf1, anticorps rnf2-a, anticorps ring1, anticorps ring1b-B, anticorps rnf2-b, anticorps ring finger protein 1, anticorps ring finger protein 1 S homeolog, anticorps ring finger protein 1 L homeolog, anticorps RING1, anticorps Ring1, anticorps ring1.S, anticorps ring1.L

Sujet: Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex act via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.

Poids moléculaire: 58 kDa

ID gène: 6015

NCBI Accession: NP_002922

UniProt: Q06587