TRPV4 anticorps (AA 301-400)

N° du produit ABIN873245

Détail du produit anti-TRPV4 anticorps

Antigène: TRPV4 (Transient Receptor Potential Cation Channel, Subfamily V, Member 4 (TRPV4))

Épitope: AA 301-400

Reactivité: Humain, Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRPV4 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Boeuf (Vache), Humain

Homologie: Mouse,Rat,Dog,Cow,Pig,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human TRPV4

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-TRPV4 (ABIN873245)

Sakakibara, Sakakibara, Kusumoto, Takeda, Hasegawa, Akashi, Minamikawa, Hashikawa, Terashi, Komori et al.: "Upregulated Expression of Transient Receptor Potential Cation Channel Subfamily V Receptors in Mucosae of Patients with Oral Squamous Cell Carcinoma and Patients with a History of Alcohol Consumption ..." dans: PLoS ONE, Vol. 12, Issue 1, pp. e0169723, (2017) (PubMed).

Détails sur TRPV4

Antigène: TRPV4 (Transient Receptor Potential Cation Channel, Subfamily V, Member 4 (TRPV4))

Autre désignation: TRP12 (TRPV4 Produits)

Synonymes: anticorps wu:fp52e02, anticorps CMT2C, anticorps HMSN2C, anticorps OTRPC4, anticorps SMAL, anticorps SPSMA, anticorps SSQTL1, anticorps TRP12, anticorps VRL2, anticorps VROAC, anticorps 0610033B08Rik, anticorps Trp12, anticorps VR-OAC, anticorps VRL-2, anticorps Otrpc4, anticorps Vroac, anticorps transient receptor potential cation channel, subfamily V, member 4, anticorps transient receptor potential cation channel subfamily V member 4, anticorps trpv4, anticorps TRPV4, anticorps Trpv4

Sujet:

Synonyms: SMAL, VRL2, BCYM3, CMT2C, SPSMA, TRP12, VROAC, HMSN2C, OTRPC4, SSQTL1, Transient receptor potential cation channel subfamily V member 4, TrpV4, Osm-9-like TRP channel 4, Transient receptor potential protein 12, Vanilloid receptor-like channel 2, Vanilloid receptor-like protein 2, VRL-2, Vanilloid receptor-related osmotically-activated channel, VR-OAC

Background: Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH , citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8.

ID gène: 59341

UniProt: Q9HBA0

Pathways: Hormone Transport, Cell-Cell Junction Organization