SLC29A4 anticorps (AA 401-500) (Alexa Fluor 647)

N° du produit ABIN915555

Détail du produit anti-SLC29A4 anticorps (Alexa Fluor 647)

Antigène: SLC29A4 (Solute Carrier Family 29 (Nucleoside Transporters), Member 4 (SLC29A4))

Épitope: AA 401-500

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SLC29A4 est conjugé à/à la Alexa Fluor 647

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Réactivité croisée: Humain, Rat

Homologie: Mouse,Dog,Cow,Pig,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human SLC29A4

Isotype: IgG

Information d'application

Indications d'application: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur SLC29A4

Antigène: SLC29A4 (Solute Carrier Family 29 (Nucleoside Transporters), Member 4 (SLC29A4))

Autre désignation: SLC29A4 (SLC29A4 Produits)

Synonymes: anticorps zgc:158679, anticorps ENT4, anticorps PMAT, anticorps mPMAT, anticorps solute carrier family 29 (equilibrative nucleoside transporter), member 4, anticorps solute carrier family 29 member 4, anticorps solute carrier family 29 (nucleoside transporters), member 4, anticorps slc29a4, anticorps SLC29A4, anticorps Slc29a4

Sujet:

Synonyms: ENT4, PMAT, Equilibrative nucleoside transporter 4, hENT4, Plasma membrane monoamine transporter, Solute carrier family 29 member 4, SLC29A4, PSEC0113

Background: Functions as a polyspecific organic cation transporter, efficiently transporting many organic cations such as monoamine neurotransmitters 1-methyl-4-phenylpyridinium and biogenic amines including serotonin, dopamine, norepinephrine and epinephrine. May play a role in regulating central nervous system homeostasis of monoamine neurotransmitters. May be involved in luminal transport of organic cations in the kidney and seems to use luminal proton gradient to drive organic cation reabsorption. Does not seem to transport nucleoside and nucleoside analogs such as uridine, cytidine, thymidine, adenosine, inosine, guanosine, and azidothymidine. In (PubMed:16873718) adenosine is efficiently transported but in a fashion highly sensitive to extracellular pH , with maximal activity in the pH range 5.5 to 6.5. Glu-206 is essential for the cation selectivity and may function as the charge sensor for cationic substrates. Transport is chloride and sodium-independent but appears to be sensitive to changes in membrane potential. Weakly inhibited by the classical inhibitors of equilibrative nucleoside transport, dipyridamole, dilazep, and nitrobenzylthioinosine. May play a role in the regulation of extracellular adenosine concentrations in cardiac tissues, in particular during ischemia.

ID gène: 222962

UniProt: Q7RTT9